Patents by Inventor Meghan Drummond-Samuelson

Meghan Drummond-Samuelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS WITH A BETA-SLIP MUTATION AND METHODS OF USE
    Publication number: 20200385760
    Abstract: Non-human animal cells and non-human animals comprising a humanized TTR locus comprising a beta-slip mutation and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TTR locus comprising a beta-slip mutation express a human transthyretin protein or a chimeric transthyretin protein, fragments of which are from human transthyretin. Methods are provided for using such non-human animals comprising a humanized TTR locus to assess in vivo efficacy of human-TTR-targeting reagents such as nuclease agents designed to target human TTR.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 10, 2020
    Inventors: Jeffery Haines, Keith Crosby, Meghan Drummond-Samuelson, David Frendewey, Brian Zambrowicz, Andrew J. Murphy
  • Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use
    Publication number: 20190098879
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TTR locus and methods of using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TTR locus express a human transthyretin protein or a chimeric transthyretin protein, fragments of which are from human transthyretin. Methods are provided for using such non-human animals comprising a humanized TTR locus to assess in vivo efficacy of human-TTR-targeting reagents such as nuclease agents designed to target human TTR. Methods are also provided for making such non-human animals comprising a humanized TTR locus.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 4, 2019
    Inventors: Meghan Drummond-Samuelson, Jeffery Haines, Suzanne Hartford, David Frendewey, Brian Zambrowicz, Andrew J. Murphy