Abstract: A catheter system is disclosed. An example catheter system includes an elongate tubular member having a distal region and a proximal end, a first balloon disposed along the distal region of the tubular member, a second balloon disposed along the distal region of the tubular member, wherein the second balloon is spaced from the first balloon. The catheter system also includes a first lumen extending within the elongate tubular member, a second lumen extending within the elongate tubular member, a first set of apertures in fluid communication with the first lumen, wherein the first set of apertures are configured to inflate both the first balloon and the second balloon and a second set of apertures in fluid communication with the first lumen, wherein the second set of apertures are configured to apply a treatment to a target site positioned between the first balloon and the second balloon.