Patents by Inventor Meharvan Singh

Meharvan Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF LET7I AS A MEANS TO ENHANCE THE PROTECTIVE EFFECT OF PROGESTERONE AGAINST STROKE
    Publication number: 20220135975
    Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 5, 2022
    Inventors: MEHARVAN SINGH, CHANG SU, TRINH NGUYEN
  • Inhibition of LET7I as a means to enhance the protective effect of progesterone against stroke
    Patent number: 11230711
    Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER
    Inventors: Meharvan Singh, Chang Su, Trinh Nguyen
  • INHIBITION OF LET7I AS A MEANS TO ENHANCE THE PROTECTIVE EFFECT OF PROGESTERONE AGAINST STROKE
    Publication number: 20200216847
    Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.
    Type: Application
    Filed: August 13, 2018
    Publication date: July 9, 2020
    Inventors: MEHARVAN SINGH, CHANG SU, TRINH NGUYEN
  • ENHANCING EFFECTIVENESS OF GLIAL CANCER THERAPIES
    Publication number: 20120040914
    Abstract: A method of enhancing the effectiveness of a chemotherapeutic agent, such as Temozolomide (TMZ), or ionizing radiation against glioblastoma is described in the present invention. The method comprises targeting putative membrane androgen receptor (termed mAR) in glioma cells to enhance the cytotoxic effects of a chemotherapeutic agent or ionizing radiation while simultaneously affording protection to neighboring neurons.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 16, 2012
    Applicant: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH
    Inventors: MEHARVAN SINGH, Adrienne Badeaux, Niki Mirshams
  • Membrane androgen receptor as a therapeutic target for the prevention/promotion of cell death
    Publication number: 20070141581
    Abstract: The present invention includes compositions, kits and methods for specifically and differentially activating a membrane androgen receptor and their use for comparing the binding specificity of one or more drugs to a membrane androgen receptor and to an intracellular androgen receptor, wherein a difference in drug binding is indicative of differential receptor binding and may be used to diagnose and treat diseases and conditions associated with androgens.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 21, 2007
    Applicant: University of North Texas Health Science Center at Fort Worth
    Inventors: Meharvan Singh, Joshua Gatson
  • Methods for neuroprotection
    Patent number: 5554601
    Abstract: A method is provided for conferring neuroprotection on a population of cells using estrogen compounds that have insubstantial sex activity and furthermore, a method is provided that utilizes estrogen compounds in the absence of testosterone for treating neurodegenerative diseases including Alzheimer's disease so as to retard the adverse effects of these disorders, Examples of estrogen compounds that have insubstantial sex activity includes alpha isomers of estrogen compounds such as 17.alpha. estradiol.
    Type: Grant
    Filed: October 4, 1994
    Date of Patent: September 10, 1996
    Assignee: University of Florida
    Inventors: James W. Simpkins, Meharvan Singh, Jean Bishop