Abstract: A monoclonal anti-HER2 antibody is mutated on complementarity determining regions (CDRs) and framework regions. The VH domain of the antibody includes a portion of the amino acid sequence as SEQ ID NO: 1. The VL domain of the antibody includes a portion of the amino acid sequence as SEQ ID NO: 5.

Abstract: A monoclonal anti-HER2 antibody is mutated on complementarity determining regions (CDRs) and framework regions. The VH domain of the antibody includes a portion of the amino acid sequence as SEQ ID NO: 1. The VL domain of the antibody includes a portion of the amino acid sequence as SEQ ID NO: 5.

Abstract: A method and apparatus are disclosed for approximating in real time the fracture fatigue entropy (FFE) of a metallic object subjected to cyclic loading. Such objects experience fatigue, which can lead to failure after a number of loading cycles. The disclosed invention allows for real time monitoring of the entropy increase in a metallic object under cyclic loading, and allows for removing the object from service before fatigue fracture occurs. Through use of the present invention, users may keep metallic objects in service for longer periods, because such objects may be safely taken closer to the fatigue fracture point. The invention therefore can effectively extend the useful life of many critical components and reduce downtime resulting from repair or premature replacement.

Abstract: Methods are disclosed relating to the assessment of fatigue damage in objects that include for example, subjecting a fatigued object to a cyclic mechanical stress, measuring a rate of temperature rise in the fatigued object, and assessing a degree of fatigue of the fatigued object based on the rate of temperature rise in the fatigued object. Methods of measuring internal structural characteristics and methods of correlating fatigue damage to results from excitation tests are also taught.

Abstract: Methods are disclosed relating to the assessment of fatigue damage in objects that include for example, subjecting a fatigued object to a cyclic mechanical stress, measuring a rate of temperature rise in the fatigued object, and assessing a degree of fatigue of the fatigued object based on the rate of temperature rise in the fatigued object. Methods of measuring internal structural characteristics and methods of correlating fatigue damage to results from excitation tests are also taught.

Abstract: A method and apparatus are disclosed for predicting the service life of a metallic structure subjected to cyclic loading. Such structures experience fatigue, which can lead to failure after a number of loading cycles. The disclosed invention allows for an accurate prediction of the number of cycles to failure for a metallic structure by observing the slope of the rise in surface temperature of the structure after the cyclic loading has begun. The method of this invention provides early and accurate predictions of service life and does not require destructive testing. The method and apparatus of the present invention may be installed on working equipment, thus providing service life predictions for materials in real world use. The invention uses an empirically derived relationship that was confirmed using analytical relationships and material properties. The derived formula uses two constants that may be determined empirically using a disclosed process. The constants also may be estimated mathematically.

Abstract: A method and apparatus are disclosed for predicting the service life of a metallic structure subjected to cyclic loading. Such structures experience fatigue, which can lead to failure after a number of loading cycles. The disclosed invention allows for an accurate prediction of the number of cycles to failure for a metallic structure by observing the slope of the rise in surface temperature of the structure after the cyclic loading has begun. The method of this invention provides early and accurate predictions of service life and does not require destructive testing. The method and apparatus of the present invention may be installed on working equipment, thus providing service life predictions for materials in real world use. The invention uses an empirically derived relationship that was confirmed using analytical relationships and material properties. The derived formula uses two constants that may be determined empirically using a disclosed process. The constants also may be estimated mathematically.