Patents by Inventor Mehdi Numa

Mehdi Numa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20120309758
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 6, 2012
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Urvi Sheth, Lev T.D. Fanning, Mehdi Numa, Hayley Binch, Dennis James Hurley, Jinglan Zhou, Sara S. Hadida Ruah, Anna R. Hazlewood, Alina Silina, Rajendran Vairagoundar, Fredrick F. Van Goor, Peter Diederik Jan Grootenhuis, Martyn C. Botfield
  • HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
    Publication number: 20120149742
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: February 22, 2012
    Publication date: June 14, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • Heterocyclic derivatives as modulators of ion channels
    Patent number: 8143297
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 27, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
    Publication number: 20110306607
    Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: May 6, 2011
    Publication date: December 15, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara Sabina Hadida-Ruah, Edward Adam Kallel, Mark Thomas Miller, Joseph Pontillo, Vijayalaksmi Arumugam, Nicole Hilgraf, Jason McCartney, Peter Diederik Jan Grootenhuis, Corey Anderson, Mehdi Numa, Bryan A. Frieman, Brian Richard Bear, James Philip Johnson, JR.
  • Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
    Publication number: 20110124869
    Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 26, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Narendra Bhalchandra Ambhaikar, Robert Hughes, Dennis James Hurley, Elaine Chungmin Lee, Benjamin Littler, Mehdi Numa, Stefanie Roeper, Urvi Sheth
  • HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
    Publication number: 20110098328
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: October 28, 2010
    Publication date: April 28, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • Modulators of ATP-binding cassette transporters
    Publication number: 20070244159
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 18, 2007
    Inventors: Sara Hadida Ruah, Peter Grootenhuis, Frederick Van Goor, Jinglan Zhou, Brian Bear, Mark Miller, Jason McCartney, Mehdi Numa