Patents by Inventor Mehmet Akçakaya

Mehmet Akçakaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200337588
    Abstract: Magnetic resonance imaging (“MRI”) data are corrected from corruptions due to physiological changes using a self-navigated phase correction technique. Unlike motion correction techniques, the effects of physiological changes (e.g., breathing and respiration) are corrected by making the MRI data self-consistent relative to an absolute uncorrupted phase reference. This phase correction information can be extracted from the acquisition itself, thereby eliminating the need for a separate navigator scan, and establishing an accelerated acquisition. This absolute reference can be computed in a data segmented space, and the subsequent data can be corrected relative to this absolute reference with low-resolution phases.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventors: Steen Moeller, Sudhir Ramanna, Mehmet Akcakaya
  • Publication number: 20200341103
    Abstract: Images are reconstructed from undersampled k-space data using a residual machine learning algorithm (e.g., a ResNet architecture) to estimate missing k-space lines from acquired k-space data with improved noise resilience. Using a residual machine learning algorithm provides for combining the advantages of both linear and nonlinear k-space reconstructions. The linear residual connection can implement a convolution that estimates most of the energy in k-space, and the multi-layer machine learning algorithm can be implemented with nonlinear activation functions to estimate imperfections, such as noise amplification due to coil geometry, that arise from the linear component.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventors: Mehmet Akcakaya, Steen Moeller, Chi Zhang
  • Publication number: 20200333416
    Abstract: A fully sampled calibration data set, which may be Cartesian k-space data, is used to obtain targeted and optimal interpolation kernels for non-regularly sampled data. The calibration data are self-calibration data obtained from a time-averaged image, or re-sampled data. ACS data are resampled for calibration of region-specific kernels. Subsequently, an explicit noise-based regularized solution can be utilized to estimate region-specific kernels for reconstruction.
    Type: Application
    Filed: April 20, 2020
    Publication date: October 22, 2020
    Inventors: Steen Moeller, Mehmet Akcakaya, Seng-Wei Chieh
  • Patent number: 10775464
    Abstract: Systems and methods for producing quantitative maps of a longitudinal relaxation parameter, such as a longitudinal relaxation time (“T1”), using magnetic resonance imaging (“MRI”) are described. More particularly, a pulse sequence and imaging method for cardiac phase-resolved myocardial T1 mapping are provided.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: September 15, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Patent number: 10768260
    Abstract: A system and method for controlling noise in magnetic resonance imaging (MRI) are provided. In one aspect, the method includes reconstructing a series of images of the target using the image data, with each image being defined using signal-to-noise (SNR) units, and selecting an image patch corresponding to the series of images. The method also includes forming a matrix by combining vectors generated using the image patch, and applying a local low rank denoising technique using the matrix and the series of images to generate at least one denoised image.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: September 8, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Steen Moeller, Mehmet Akcakaya
  • Patent number: 10739420
    Abstract: Systems and methods for mapping the transmit sensitivity of one or more radio frequency (“RF”) coils for use in magnetic resonance imaging (“MRI”) are described. The transmit RF field (“B1+”) for an RF coil, or an array of RF coils, is mapped using a robust, motion-insensitive technique that implements Bloch-Siegert shifts performed with interleaved positive and negative off-resonance shifts. The motion insensitivity of this technique makes it particularly useful for applications where there is significant motion, such as cardiac imaging, in which previous B1+ mapping techniques are not as accurate or effective.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: August 11, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Publication number: 20200041591
    Abstract: Systems and methods for late gadolinium enhancement (“LGE”) tissue viability imaging in a dynamic (e.g., temporal-ly-resolved) manner using magnetic resonance imaging (“MRI”) are provided. Dynamic LGE images can be generated throughout the entire cardiac cycle at high temporal resolution in a single breath-hold. Dynamic, semi-quantitative longitudinal relaxation maps are acquired and retrospective synthetization of dynamic LGE images is implemented using those semi-quantitative longitudinal relaxation maps.
    Type: Application
    Filed: January 31, 2018
    Publication date: February 6, 2020
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Patent number: 10531812
    Abstract: A system and method for controlling a magnetic resonance imaging (MRI) system to acquire images of a subject having inconsistencies in a cardiac cycle of the subject. The process includes receiving an identification of a predetermined point in a cardiac cycle of the subject and, thereupon, performing a saturation module configured to dephase magnetization within a region of interest (ROI) from before the predetermined point. The process also includes performing an inversion module configured to invert spins within the ROI and acquiring medical imaging data from the subject. A delay is inserted between the performance of the saturation module and the performance of the inversion module, wherein a duration of the delay is configured, with the saturation module, to control evidence in the medical imaging data of inconsistencies in the cardiac cycle of the subject by controlling a magnetization history of tissue in the ROI.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: January 14, 2020
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Sebastian Weingärtner, Mehmet Akçakaya, Warren J. Manning, Reza Nezafat
  • Patent number: 10451700
    Abstract: A system and method for obtaining magnetic resonance images are provided. The system is programmed to control the RF system to apply a saturation pulse at a reference frequency that saturates a selected labile spin species of the subject. The system is programmed to control the RF system to apply an inversion pulse after a variable delay. The system is programmed to control the RF system and the plurality of gradient coils to apply a motion sensitized driven equilibrium (MSDE) preparation pulse. The system is programmed to control the plurality of gradient coils to read imaging data during an acquisition time period. The system is programmed to reconstruct a T1 mapping image of the subject with black-blood contrast.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: October 22, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Patent number: 10330760
    Abstract: An MRI apparatus includes: a data processor configured to acquire a first set of T2-weighted imaging data and a second set of T2-weighted imaging data; a pulse sequence controller configured to generate a pulse sequence and apply the generated pulse sequence to a gradient coil assembly and RF coil assembly, the generated pulse sequence including: T2-preparation modules and associated imaging modules to acquire the first set of T2-weighted imaging data, and a saturation pulse sequence and an associated saturation imaging module to acquire the second set of T2-weighted imaging data; a curve fitter configured to apply the first and second sets of T2-weighted imaging data to a three-parameter model for T2 decay, to determine a T2 value at a plurality of locations; and an image processor configured to generate a T2 map of the object based on the T2 value determined at the plurality of locations.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 25, 2019
    Assignee: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Mehmet Akcakaya, Tamer Basha, Warren J. Manning, Reza Nezafat
  • Publication number: 20190086496
    Abstract: A system and method for controlling noise in magnetic resonance imaging (MRI) are provided. In one aspect, the method incudes reconstructing a series of images of the target using the image data, with each image being defined using signal-to-noise (SNR) units, and selecting an image patch corresponding to the series of images. The method also includes forming a matrix by combining vectors generated using the image patch, and applying a local low rank denoising technique using the matrix and the series of images to generate at least one denoised image.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Steen Moeller, Mehmet Akcakaya
  • Publication number: 20180292487
    Abstract: Methods for fast magnetic resonance imaging (“MRI”) using a combination of outer volume suppression (“OVS”) and accelerated imaging, which may include simultaneous multislice (“SMS”) imaging, data acquisitions amenable to compressed sensing reconstructions, or combinations thereof. The methods described here do not introduce fold-over artifacts that are otherwise common to reduced field-of-view (“FOV”) techniques.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Inventors: Sebastian Weingartner, Steen Moeller, Mehmet Akcakaya
  • Publication number: 20180292488
    Abstract: Described here are systems and methods for volumetric excitation in magnetic resonance imaging (“MRI”) using frequency modulated radio frequency (“RF”) pulses. In general, quadratic phase modulation along the slice encoding direction is implemented for additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates that are robust to slice-undersampling.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Inventors: Steen Moeller, Mehmet Akcakaya
  • Publication number: 20180217217
    Abstract: Systems and methods for producing quantitative maps of a longitudinal relaxation parameter, such as a longitudinal relaxation time (“T1”), using magnetic resonance imaging (“MRI”) are described. More particularly, a pulse sequence and imaging method for cardiac phase-resolved myocardial T1 mapping are provided.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 2, 2018
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Publication number: 20180067184
    Abstract: A system and method for obtaining magnetic resonance images are provided. The system is programmed to control the RF system to apply a saturation pulse at a reference frequency that saturates a selected labile spin species of the subject. The system is programmed to control the RF system to apply an inversion pulse after a variable delay. The system is programmed to control the RF system and the plurality of gradient coils to apply a motion sensitized driven equilibrium (MSDE) preparation pulse. The system is programmed to control the plurality of gradient coils to read imaging data during an acquisition time period. The system is programmed to reconstruct a T1 mapping image of the subject with black-blood contrast.
    Type: Application
    Filed: September 5, 2017
    Publication date: March 8, 2018
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Publication number: 20180067176
    Abstract: Systems and methods for mapping the transmit sensitivity of one or more radio frequency (“RF”) coils for use in magnetic resonance imaging (“MRI”) are described. The transmit RF field (“B1+”) for an RF coil, or an array of RF coils, is mapped using a robust, motion-insensitive technique that implements Bloch-Siegert shifts performed with interleaved positive and negative off-resonance shifts. The motion insensitivity of this technique makes it particularly useful for applications where there is significant motion, such as cardiac imaging, in which previous B1+ mapping techniques are not as accurate or effective.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 8, 2018
    Inventors: Sebastian Weingartner, Mehmet Akcakaya
  • Patent number: 9835705
    Abstract: A magnetic resonance imaging (MRI) system and methods are provided for producing images of a subject. In some aspects, a method includes identifying a point in the cardiac cycle, performing an inversion recovery (IR) pulse at a selected time point from the pre-determined point, and sampling a k-space segment at an inversion time from the IR pulse that is substantially coincident with the pre-determined point. The method also includes repeating the IR pulse and k-space sampling for multiple inversion times, and multiple segments of k-space, in an interleaved manner, to generate datasets having T1-weighted contrasts determined by their respective inversion times. The method further includes reconstructing three-dimensional (3D) spatially-aligned images using the datasets, and generating a T1 recovery map by combining the 3D images. In some aspects, a prospective/retrospective scheme may be used to obtain data fully sampled in the center of k-space and randomly undersampled in the outer regions.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 5, 2017
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Sebastian Weingartner, Mehmet Akcakaya, Reza Nezafat
  • Patent number: 9651641
    Abstract: A magnetic resonance (MR) image processing system includes a data collection unit that acquires image data from a target region of an object. A navigator unit acquires a motion signal indicating motion comprising motion of at least a portion of an object. A data processing unit derives k-space data for a k-space data array from the acquired image data, by acquiring k-space data for a first portion of the k-space from the acquired image data in response to the motion signal indicating motion is within a predetermined range and acquiring k-space data for a second portion of the k-space from the acquired image data irrespective of the predetermined range.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 16, 2017
    Assignees: Samsung Electronics Co., Ltd., Beth Israel Deaconess Medical Center, Inc. (BIDMC, INC.)
    Inventors: Gulaka Praveen, Mehmet Akcakaya, Reza Nezafat
  • Patent number: 9202272
    Abstract: An apparatus and method process image data, including motion corrupted data, from a magnetic resonance imaging procedure to obtain and reconstruct images for cardiac, cardiovascular, coronary arterial, and/or pulmonary vein diagnoses in a subject. The apparatus and method include a processor operating predetermined software which receives the image data, classifies the received image data as accepted image data or rejected image data, and applies a predetermined relationship between the accepted image data and the rejected image data to correct for motion of the subject and to generate and output a reconstructed image of the subject corrected for the motion from the image data, with the reconstructed image having a relatively high signal-to-noise ratio.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: December 1, 2015
    Assignee: Beth Israel Deaconess Medical Center, Inc. (BIDMC, INC.)
    Inventors: Mehmet Akcakaya, Jaime L Shaw, Reza Nezafat, Sebastien Roujol
  • Publication number: 20150268320
    Abstract: An MRI apparatus includes: a data processor configured to acquire a first set of T2-weighted imaging data and a second set of T2-weighted imaging data; a pulse sequence controller configured to generate a pulse sequence and apply the generated pulse sequence to a gradient coil assembly and RF coil assembly, the generated pulse sequence including: T2-preparation modules and associated imaging modules to acquire the first set of T2-weighted imaging data, and a saturation pulse sequence and an associated saturation imaging module to acquire the second set of T2-weighted imaging data; a curve fitter configured to apply the first and second sets of T2-weighted imaging data to a three-parameter model for T2 decay, to determine a T2 value at a plurality of locations; and an image processor configured to generate a T2 map of the object based on the T2 value determined at the plurality of locations.
    Type: Application
    Filed: March 20, 2015
    Publication date: September 24, 2015
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Mehmet AKCAKAYA, Tamer BASHA, Warren J. MANNING, Reza NEZAFAT