Patents by Inventor Mehmet Fatih Yanik
Mehmet Fatih Yanik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240009436Abstract: In a method for enhancing localized delivery of a diagnostic or therapeutic agent using focused ultrasound (FUS), ultrasound-controllable drug carriers are administered into a blood vessel. Each drug carrier comprises an ultrasound-sensitive microbubble loaded with the diagnostic or therapeutic agent. The drug carriers are aggregated inside the vessel both along a radial direction and a longitudinal direction by application of an aggregation FUS sequence. Subsequently the diagnostic or therapeutic agent is released from the drug carriers by application of an uncaging FUS sequence. The aggregation and uncaging sequences are applied using FUS below a threshold power level such that harmful cavitation is avoided, as evidenced by the absence of broadband emissions and preferably non-integer harmonics from an emission spectrum of the drug carriers. Thereby damage to the vasculature by the FUS sequence is avoided.Type: ApplicationFiled: August 16, 2021Publication date: January 11, 2024Applicant: ETH ZurichInventors: Mehmet Fatih YANIK, Mehmet OZDAS, Aagam SHAH, Paul JOHNSON, Shashank SIRSI
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Patent number: 10837020Abstract: The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.Type: GrantFiled: April 25, 2012Date of Patent: November 17, 2020Assignee: Massachusetts Institute of TechnologyInventors: Mehmet Fatih Yanik, Matthew Angel
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Publication number: 20160051353Abstract: Automatic system for efficient delivery of biologics into target organs of zebrafish larvae for high-throughput in vivo screening. The system includes a reservoir containing zebrafish larvae immersed in a hydrogel in its liquid state. A microfluidic component removes a droplet of the hydrogel having a single zebrafish larva contained therein and deposits the droplet on a surface for receiving an array of hydrogel droplets. Structure or substances is provided for inducing the larva to assume a dorsal or lateral orientation within the droplet. A cooler cools the surface to solidify the hydrogel droplets thereby to immobilize the larvae for observation by an optical arrangement that identifies target organs in each larva using an image template-matching algorithm. A pressure driven microinjection needle injects biologics into the target organ of the zebrafish larva for screening studies.Type: ApplicationFiled: August 10, 2015Publication date: February 25, 2016Inventors: Mehmet Fatih Yanik, Tsung-Yao Chang, Peng Shi
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Publication number: 20140073053Abstract: The present disclosure provides culture media and methods of using culture media for efficient transfection of a target cell with nucleic acid molecules. The media is capable of supporting cells in culture that are differentiating, transdifferentiating, and/or dedifferentiating.Type: ApplicationFiled: September 6, 2013Publication date: March 13, 2014Applicant: Massachusetts Institute of TechnologyInventors: Mehmet Fatih Yanik, Matthew Angel
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Publication number: 20120208278Abstract: The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.Type: ApplicationFiled: April 25, 2012Publication date: August 16, 2012Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Mehmet Fatih Yanik, Matthew Angel
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Publication number: 20100273220Abstract: The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.Type: ApplicationFiled: April 22, 2009Publication date: October 28, 2010Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: MEHMET FATIH YANIK, MATTHEW ANGEL
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Patent number: 7803712Abstract: A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.Type: GrantFiled: December 7, 2006Date of Patent: September 28, 2010Assignee: Hewlett-Packard Development Company, L.P.Inventors: Pavel Kornilovich, Yong Chen, Duncan Stewart, R. Stanley Williams, Philip J. Kuekes, Mehmet Fatih Yanik
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Publication number: 20100112809Abstract: A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.Type: ApplicationFiled: December 7, 2006Publication date: May 6, 2010Inventors: Pavel Kornilovich, Yong Chen, Duncan Stewart, R. Stanley Williams, Philip J. Kuekes, Mehmet Fatih Yanik
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Patent number: 7412127Abstract: We introduce a mechanically tunable photonic crystal structure consisting of coupled photonic crystal slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that the transmission and reflection coefficients for light normally incident upon such structures can be highly sensitive to nano-scale variations in the spacing between the slabs. Moreover, by specifically configuring the photonic crystal structures, the high sensitivity can be preserved in spite of significant fabrication-related disorders. We expect such a structure to play important roles in micro-mechanically tunable optical sensors and filters.Type: GrantFiled: August 15, 2006Date of Patent: August 12, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Wonjoo Suh, Mehmet Fatih Yanik, Olav Solgaard, Shanhui Fan
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Patent number: 7269313Abstract: Light pulses can be stopped and stored coherently, with an all-optical process that involves an adiabatic and reversible pulse bandwidth compression occurring entirely in the optical domain. Such a process overcomes the fundamental bandwidth-delay constraint in optics, and can generate arbitrarily small group velocities for light pulses with a given bandwidth, without the use of any coherent or resonant light-matter interactions. This is accomplished only by small refractive index modulations performed at moderate speeds and has applications ranging from quantum communications and computing to coherent all-optical memory devices. A complete time reversal and/or temporal/spectral compression and expansion operation on any electromagnetic field is accomplished using only small refractive index modulations and linear optical elements.Type: GrantFiled: November 30, 2004Date of Patent: September 11, 2007Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mehmet Fatih Yanik, Shanhui Fan
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Patent number: 7256435Abstract: A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.Type: GrantFiled: June 2, 2003Date of Patent: August 14, 2007Assignee: Hewlett-Packard Development Company, L.P.Inventors: Pavel Kornilovich, Yong Chen, Duncan Stewart, R. Stanley Williams, Philip J. Kuekes, Mehmet Fatih Yanik
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Patent number: 7155087Abstract: We introduce a mechanically tunable photonic crystal structure consisting of coupled photonic crystal slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that the transmission and reflection coefficients for light normally incident upon such structures can be highly sensitive to nano-scale variations in the spacing between the slabs. Moreover, by specifically configuring the photonic crystal structures, the high sensitivity can be preserved in spite of significant fabrication-related disorders. We expect such a structure to play important roles in micro-mechanically tunable optical sensors and filters.Type: GrantFiled: October 8, 2003Date of Patent: December 26, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Wonjoo Suh, Mehmet Fatih Yanik, Olav Solgaard, Shanhui Fan
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Patent number: 7116864Abstract: We introduce a new all-optical mechanism that can compress the bandwidth of light pulses to absolute zero, and bring them to a complete stop. The mechanism can be realized in a system consisting of a waveguide side-coupled to tunable resonators, which generates a photonic band structure that represents a classical analogue of the Electromagnetically Induced Transparency. The same system can also achieve a time-reversal operation. We demonstrate the operation of such a system by finite-difference time-domain simulations of an implementation in photonic crystals.Type: GrantFiled: November 30, 2004Date of Patent: October 3, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mehmet Fatih Yanik, Wonjoo Suh, Zhang Wang, Shanhui Fan
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Publication number: 20060115211Abstract: We introduce a new all-optical mechanism that can compress the bandwidth of light pulses to absolute zero, and bring them to a complete stop. The mechanism can be realized in a system consisting of a waveguide side-coupled to tunable resonators, which generates a photonic band structure that represents a classical analogue of the Electromagnetically Induced Transparency. The same system can also achieve a time-reversal operation. We demonstrate the operation of such a system by finite-difference time-domain simulations of an implementation in photonic crystals.Type: ApplicationFiled: November 30, 2004Publication date: June 1, 2006Inventors: Mehmet Fatih Yanik, Wonjoo Suh, Zheng Wang, Shanhui Fan