Patents by Inventor Mehmet Pamukcu

Mehmet Pamukcu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Accurate measurement of glutathione for disease diagnosis and drug metabolite screening
    Patent number: 11885821
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: January 30, 2024
    Assignee: Definitek, Inc.
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • Quantification of previously undetectable quantities
    Patent number: 11728147
    Abstract: The present invention centers upon a novel “molecular amplification spike,” which is an admixture of two components, namely, an aliquot of a quantity of a molecule, composition, compound or element of interest (an “analyte”) in its natural isotopic state and an aliquot of an isotopically enriched form of the same molecule, composition, compound or element. The molecular amplification spike contains 20% natural-abundance isotope, balance enriched isotope. The molecular amplification spike may optionally contain more than 20% natural-abundance isotope, with concomitantly reduced balance of enriched isotope. Such an admixed spike, when added to a sample prior to mass spectrometric analysis of that sample, creates new and significantly improved percentage of errors and quantification or confirmation of the absence of the molecule, composition, compound or element of interest in the sample.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: August 15, 2023
    Assignee: Definitek, Inc.
    Inventors: Mehmet Pamukcu, Howard M. Kingston
  • Accurate Measurement of Glutathione for Disease Diagnosis and Drug Metabolite Screening
    Publication number: 20210318339
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Application
    Filed: February 18, 2021
    Publication date: October 14, 2021
    Applicant: Definitek, Inc.
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • Accurate measurement of glutathione for disease diagnosis and drug metabolite screening
    Patent number: 10962556
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: March 30, 2021
    Assignee: Definitek, Inc.
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • ACCURATE MEASUREMENT OF GLUTATHIONE FOR DISEASE DIAGNOSIS AND DRUG METABOLITE SCREENING
    Publication number: 20180299471
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 18, 2018
    Applicant: Definitek, Inc.
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • Accurate measurement of glutathione for disease diagnosis and drug metabolite screening
    Patent number: 9869684
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: January 16, 2018
    Assignee: Definitek, Inc.
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • Accurate Measurement of glutathione for disease diagnosis and drug metabolite screening
    Publication number: 20130158886
    Abstract: A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient.
    Type: Application
    Filed: June 22, 2012
    Publication date: June 20, 2013
    Inventors: Howard M. Kingston, Mehmet Pamukcu
  • Solid phase and catalyzed enabled automated isotope dilution and speciated isotope dilution mass spectrometry
    Patent number: 8383420
    Abstract: A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: February 26, 2013
    Assignees: Applied Isotope Technologies, Inc.
    Inventors: Howard M. Kingston, Mizanur Rahman, David Lineman, Mehmet Pamukcu
  • SOLID PHASE AND CATALYZED ENABLED AUTOMATED ISOTOPE DILUTION AND SPECIATED ISOTOPE DILUTION MASS SPECTROMETRY
    Publication number: 20120142545
    Abstract: A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 7, 2012
    Inventors: Howard M. Kingston, Mizanur Rahman, David Lineman, Mehmet Pamukcu