Patents by Inventor Mehrije FERIZI

Mehrije FERIZI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ATP-binding cassette family coding polyribonucleotides and formulations thereof
    Patent number: 11479768
    Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 25, 2022
    Assignee: Ethris GmbH
    Inventors: Christian Plank, Carsten Rudolph, Manish Kumar Aneja, Ludwig Weiss, Mehrije Ferizi, Johannes Geiger
  • UTRs increasing the translation efficiency of RNA molecules
    Patent number: 11136585
    Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 5, 2021
    Assignee: ethris GmbH
    Inventors: Carsten Rudolph, Manish Kumar Aneja, Mehrije Ferizi, Johannes Geiger
  • UTRs INCREASING THE TRANSLATION EFFICIENCY OF RNA MOLECULES
    Publication number: 20190194669
    Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.
    Type: Application
    Filed: June 30, 2016
    Publication date: June 27, 2019
    Applicant: Ethris GmbH
    Inventors: Carsten Rudolph, Manish Kumar Aneja, Mehrije Ferizi, Johannes Geiger
  • ATP-BINDING CASSETTE FAMILY CODING POLYRIBONUCLEOTIDES AND FORMULATIONS THEREOF
    Publication number: 20180371456
    Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.
    Type: Application
    Filed: June 30, 2016
    Publication date: December 27, 2018
    Applicant: Ethris GmbH
    Inventors: Christian PLANK, Carsten RUDOLPH, Manish Kumar ANEJA, Ludwig WEISS, Mehrije FERIZI, Johannes GEIGER