Patents by Inventor Mei-Hsiu Lai

Mei-Hsiu Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of alpha-1 antitrypsin
    Patent number: 11884672
    Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: January 30, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Upul Keerthi Bandarage, Cavan McKeon Bligh, Diane Boucher, Michael John Boyd, Michael Aaron Brodney, Michael Philip Clark, Veronique Damagnez, Lev Tyler Dewey Fanning, Robert Francis Fimognari, Gabrielle Simone Fleming, Kevin James Gagnon, Pedro Manuel Garcia Barrantes, Robert Daniel Giacometti, Simon Giroux, Ronald Lee Grey, Jr., Samantha Guido, Amy Beth Hall, Sarah Carol Hood, Dennis James Hurley, Mac Arthur Johnson, Jr., Peter Jones, Sarathy Kesavan, Mei-Hsiu Lai, Siying Liu, Adam Looker, Brad Maxwell, John Patrick Maxwell, Ales Medek, Philippe Marcel Nuhant, Kirk Alan Overhoff, Setu Roday, Stefanie Roeper, Steven M. Ronkin, Rupa Sawant, Yi Shi, Muna Shrestha, Marisa Sposato, Kathy Stavropoulos, Rebecca Jane Swett, Timothy Lewis Tapley, Qing Tang, Stephen Thomson, Jinwang Xu, Mariam Zaky, Kevin Michael Cottrell
  • SOLID FORMS OF 4-(5-(4-FLUOROPHENYL)-6-(TETRAHYDRO-2H-PYRAN-4-YL)-1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)BENZOIC ACID
    Publication number: 20240002386
    Abstract: Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).
    Type: Application
    Filed: November 17, 2021
    Publication date: January 4, 2024
    Inventors: Yi SHI, Mei-Hsiu LAI, Ales MEDEK, Kan-Nian HU, Zhengtian SONG, Elisa A. TORRICO GUZMAN, Kathleen Paige SOKOLOWSKY, Simon GIROUX, Siying LIU, Kirk Alan OVERHOFF, Setu RODAY, Rupa SAWANT, Marisa SPOSATO
  • SOLID FORMS OF APOL1 INHIBITORS AND METHODS OF USING SAME
    Publication number: 20230119114
    Abstract: The disclosure provides novel solid state forms of Compound I chosen from Compound I Phosphate Salt Hydrate Form A, Compound I free form Monohydrate, Compound I Phosphate Salt Methanol Solvate, and Compound I Phosphate Salt MEK Solvate, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease). Also provided herein are novel solid state forms of Compound II chosen from Compound II Phosphate Salt Hemihydrate Form A, Compound II free form Hemihydrate Form A, and Compound II free form Form C, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease).
    Type: Application
    Filed: August 25, 2022
    Publication date: April 20, 2023
    Inventors: Kevin Brett DANIEL, Lori Ann FERRIS, Kevin James GAGNON, Michael David JUDELSON, Mei-Hsiu LAI, Courtney K. MAGUIRE, Ales MEDEK, Andrey PERESYPKIN, Peter Jamison ROSE, Yi SHI, Charlene TSAY
  • SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME
    Publication number: 20210246121
    Abstract: The disclosure provides novel solid state forms of Compound I selected from Form B, citric acid cocrystal Form A, piperazine cocrystal Form A, urea cocrystal Form A, nicotinamide cocrystal Form A, nicotinamide cocrystal Form B, aspartame cocrystal Form A, glutaric acid cocrystal Form A, L-proline cocrystal Form A, L-proline cocrystal Form B, vanillin cocrystal Form A, and 2-pyridone cocrystal Form A, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.
    Type: Application
    Filed: February 3, 2021
    Publication date: August 12, 2021
    Inventors: Mei-Hsiu LAI, Jicong LI, Muna SHRESTHA, Ales MEDEK, Yi SHI, Andrey PERESYPKIN, Michael JUDELSON, Jack MINCHOM, Courtney MAGUIRE, Kevin GAGNON, Faith WITKOS, Satish Kumar IYEMPERUMAL, Kanika SARPAL
  • MODULATORS OF ALPHA-1 ANTITRYPSIN
    Publication number: 20200361939
    Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
    Type: Application
    Filed: May 13, 2020
    Publication date: November 19, 2020
    Inventors: Upul Keerthi BANDARAGE, Cavan McKeon BLIGH, Diane BOUCHER, Michael John BOYD, Michael Aaron BRODNEY, Michael Philip CLARK, Veronique DAMAGNEZ, Lev Tyler Dewey FANNING, Robert Francis FIMOGNARI, Gabrielle Simone FLEMING, Kevin James GAGNON, Pedro Manuel GARCIA BARRANTES, Robert Daniel GIACOMETTI, Simon GIROUX, Ronald Lee GREY, Jr., Samantha GUIDO, Amy Beth HALL, Sarah Carol HOOD, Dennis James HURLEY, Mac Arthur JOHNSON, Jr., Peter Jones, Sarathy KESAVAN, Mei-Hsiu LAI, Siying LIU, Adam LOOKER, Brad MAXWELL, John Patrick MAXWELL, Ales MEDEK, Philippe Marcel NUHANT, Kirk Alan OVERHOFF, Setu RODAY, Stefanie ROEPER, Steven M. RONKIN, Rupa SAWANT, Yi SHI, Muna SHRESTHA, Marisa SPOSATO, Kathy STAVROPOULOS, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Qing TANG, Stephen THOMSON, Jinwang XU, Mariam ZAKY
  • Microencapsulated aminosiloxanes for protective material formulations
    Patent number: 10196491
    Abstract: Disclosed herein are methods and formulations for the microencapsulation of aminosiloxanes, for example for use as an additive in protective material formulations such as those used in the protection and/or joining of metal substrates. The additives may be used in conjunction with a second reactant that may or may not be similarly microencapsulated for self-healing (and associated corrosion resistance) or delayed cure applications, or they may be used alone or in conjunction with other corrosion inhibitors for protective formulations with improved corrosion resistance on appropriate substrates.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 5, 2019
    Assignee: Autonomic Materials, Inc.
    Inventors: Gerald O. Wilson, Subramanyam V. Kasisomayajula, Mei-Hsiu Lai, Christopher R. Dayton, Angela C. Smith
  • MICROENCAPSULATED AMINOSILOXANES FOR PROTECTIVE MATERIAL FORMULATIONS
    Publication number: 20170166709
    Abstract: Disclosed herein are methods and formulations for the microencapsulation of aminosiloxanes, for example for use as an additive in protective material formulations such as those used in the protection and/or joining of metal substrates. The additives may be used in conjunction with a second reactant that may or may not be similarly microencapsulated for self-healing (and associated corrosion resistance) or delayed cure applications, or they may be used alone or in conjunction with other corrosion inhibitors for protective formulations with improved corrosion resistance on appropriate substrates.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 15, 2017
    Inventors: Gerald O. Wilson, Subramanyam V. Kasisomayajula, Mei-Hsiu Lai, Christopher R. Dayton, Angela C. Smith