Abstract: A metal product includes a metal substrate, at least one first hole, at least one second hole, and at least one third hole. The first hole is formed in a surface of the metal substrate. The second hole is formed in at least one of a portion of the surface of the metal substrate without the first hole and an inner surface defining the first hole. The third hole is formed in at least one of a portion of the surface of the metal substrate without the first hole and without the second hole, a portion of the inner surface defining the first hole without the second hole, and an inner surface defining the second hole. The first, second, and third holes enhance a bonding strength between the metal product and a material product. The disclosure also provides a metal composite and a method for manufacturing the metal product.

Abstract: The present invention relates to an antagonist of interleukin-17B receptor (IL-17RB) which features interruption of the interaction of IL-17RB and MLK4. The present invention also relates to use of such antagonist for treatment of diseases or disorders associated with IL-17RB activation. Further disclosed is a phosphorylated IL-17RB as a biomarker for predicting prognosis and/or monitoring progression of cancer.

Abstract: A dual-band HP omnidirectional antenna includes an electrically small (ES) first omnidirectional loop antenna for a first band, and a second omnidirectional loop antenna for a second band. The first omnidirectional loop antenna and the second omnidirectional loop antenna are capable of operating independently in the first band and the second band. A loading effect of the second omnidirectional loop antenna adapted to suppress a higher-order mode of the first omnidirectional loop antenna.

Abstract: Disclosed is a process cartridge detachably mounted to an image forming device having a tray and force applying components. The process cartridge has a process cartridge frame, a photosensitive unit, a developing unit rotatable relative to the photosensitive unit. The process cartridge frame has a driving side and a conductive side disposed oppositely along a length direction. The driving side has a first driving force receiving portion for rotating a photosensitive drum and a second driving force receiving portion for rotating a developing roller. The developing unit has a force receiving portion for receiving force of force applying components to rotate the developing unit relative to the photosensitive unit. When the process cartridge is pushed into to the image forming device, the force receiving portion move at least in a left-and-right direction and/or an up-and-down direction relative to the frame of the process cartridge.

Abstract: A processor-implemented method is disclosed.

Abstract: A method for providing a dynamic user interface for navigating user account data is disclosed. The method includes: performing a first data transfer from a user account; updating an interaction model for the user account based on the first data transfer; receiving, from a client device associated with the user account, a query having at least one query term; determining, based on the interaction model and the at least one query term, that the query maps to a user intent associated with the first data transfer; and in response to determining that the query maps to a user intent associated with the first data transfer, providing, to the client device, a search result based on the first data transfer.

Abstract: A metal product includes a metal substrate, at least one first hole, at least one second hole, and at least one third hole. The first hole is formed in a surface of the metal substrate. The second hole is formed in at least one of a portion of the surface of the metal substrate without the first hole and an inner surface defining the first hole. The third hole is formed in at least one of a portion of the surface of the metal substrate without the first hole and without the second hole, a portion of the inner surface defining the first hole without the second hole, and an inner surface defining the second hole. The first, second, and third holes enhance a bonding strength between the metal product and a material product. The disclosure also provides a metal composite and a method for manufacturing the metal product.

Abstract: A method for providing a dynamic user interface for navigating user account data is disclosed. The method includes: performing a first data transfer from a user account; updating an interaction model for the user account based on the first data transfer; receiving, from a client device associated with the user account, a query having at least one query term; determining, based on the interaction model and the at least one query term, that the query maps to a user intent associated with the first data transfer; and in response to determining that the query maps to a user intent associated with the first data transfer, providing, to the client device, a search result based on the first data transfer.

Abstract: An in situ phase change gel sustained-release preparation for a small molecule drug and a preparation method thereof. The in situ phase change gel sustained-release preparation comprises a small molecule drug comprising an active pharmaceutical ingredient, a phospholipid, Span, and an ethanol solution. The in situ phase change gel sustained-release preparation has a high concentration of phospholipids combined with Span, and is thus able to reduce the immediate-release of the small molecule drug and extend the release time, and is suitable for various administration routes, such as subcutaneous injection and external administration.

Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.

Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.

Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.

Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.

Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.

Abstract: A display panel have a transmissive region and a reflective region. The display panel comprises a first plate, a second plate opposite to the first plate and a display medium. The first plate comprises a first substrate, a scan line, a data line, an active device, a common electrode, a pixel electrode and a dielectric layer. The active device is electrically connected to the scan line and the data line. The pixel electrode is electrically connected to the active device and is electrically insulated from the common electrode. The pixel electrode has slits exposing the common electrode. The dielectric layer is located between the common electrode and the pixel electrode and has first openings in the reflective region. The second plate is opposite to the first plate. The display medium is located between the first plate and the second plate.

Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.

Abstract: A display panel have a transmissive region and a reflective region. The display panel comprises a first plate, a second plate opposite to the first plate and a display medium. The first plate comprises a first substrate, a scan line, a data line, an active device, a common electrode, a pixel electrode and a dielectric layer. The active device is electrically connected to the scan line and the data line. The pixel electrode is electrically connected to the active device and is electrically insulated from the common electrode. The pixel electrode has slits exposing the common electrode. The dielectric layer is located between the common electrode and the pixel electrode and has first openings in the reflective region. The second plate is opposite to the first plate. The display medium is located between the first plate and the second plate.

Abstract: A pharmaceutical composition for preventing and/or treating bone loss is disclosed. The pharmaceutical composition includes an effective amount of a licorice, black bean, Cnidi Fructus, and buckhorn.

Abstract: A nematic liquid crystal composition includes a mixture of first component and second component as follows: a first component with at least one first twisted-related characteristic, wherein the first component is from 75% to 90% in total weight of the nematic liquid crystal composition; and a second component with at least one second twisted-related characteristic lower than the first twist-related characteristics, wherein the second component is from 10% to 25% in total weight of the nematic liquid crystal composition.

Abstract: A signal transmitting circuit includes a driving circuit, and a plurality of receiving circuits receiving signals transmitted from the driving circuit. Each of the receiving circuits is coupled to the driving circuit consecutively via a transmission line. A voltage regulator is coupled to the driving circuit and the receiving circuits and provides power to the driving circuit and the receiving circuits. A number of capacitors are coupled between the voltage regulator and the ground for filtering the noise of the power output from the voltage regulator. The capacitors between the voltage regulator and the north bridge chipset filtering the noise of the power output from the voltage regulator maintain signal integrity as the terminal resistor does. It is of advantage that the signal transmitting circuit is simple to manufacture and very suitable for mass production.