Abstract: 5-methoxy-7-hydroxyflavan compound (I) was isolated and purified from Dragon's Blood resin. The purification process involves 50% ethanol soxhletion overnight and then fraction through silica column with a series of solvent elution. The purified compound (I) was crystallized in benzene: hexane (1:1). The pure compound was identified by instruments including IR, NMR, FAB-MS, and GC-MS and acetylation reaction to confirm the structure. This compound was found to be a strong antifungal chemical with broad spectra against Fusarium oxysporium fsp. niveum, Phytophora capsici, Phoma asparagi, Pythium spinosum, Pythium aphanidermatum, Phthium sylvaticum, Sclerotium rolfsii, and Sclerotinia sclerotiorum . For whole plant in vivo testes, it was found that compound (I) significantly protected mung bean and cabbage from being infested and damaged by Sclerotium rolfsii and Pythium aphanidermatum respectively.