Patents by Inventor Mei Ling Ho
Mei Ling Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240055351Abstract: An interconnect structure including a dielectric structure, plugs, and conductive lines is provided. The dielectric structure is disposed on a substrate. The plugs are disposed in the dielectric structure. The conductive lines are disposed in the dielectric structure and are electrically connected to the plugs. The sidewall of at least one of the conductive lines is in direct contact with the dielectric structure.Type: ApplicationFiled: September 13, 2022Publication date: February 15, 2024Applicant: Powerchip Semiconductor Manufacturing CorporationInventors: Shou-Zen Chang, Mei Ling Ho, Tien-Lu Lin, Ming-Han Liao, Chia-Ming Wu, Jui-Neng Tu
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Patent number: 11344548Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.Type: GrantFiled: October 8, 2015Date of Patent: May 31, 2022Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Chai-Lin Kao, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20210322411Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.Type: ApplicationFiled: October 8, 2015Publication date: October 21, 2021Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Chai-Lin Kao, Je-Ken Chang, Mei-Ling Ho
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Patent number: 11111184Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.Type: GrantFiled: December 2, 2016Date of Patent: September 7, 2021Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chih-Kuang Wang, Mei-Ling Ho, Li-Cheng Pan, Yin-Chih Fu, Chung-Hwan Chen, Je-Ken Chang
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Publication number: 20210162074Abstract: The present invention relates to a method for treating or alleviating an osteoporosis in a subject. The method comprises steps of identifying the subject having the osteoporosis, and administering to the subject an effective amount of a composition that increases a level of Discoidin Domain Receptor 1 (DDR1) protein in the subject.Type: ApplicationFiled: February 5, 2021Publication date: June 3, 2021Applicant: Kaohsiung Medical UniversityInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Patent number: 10946021Abstract: The present invention relates to a use of Discoidin Domain Receptor 1 (DDR1) inhibitor in preparing a medicament for preventing or treating a joint disease. The present invention further relates to a use of DDR1 activator in preparing a medicament for preventing or treating abnormalities of endochondral ossification-related conditions.Type: GrantFiled: March 23, 2018Date of Patent: March 16, 2021Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Publication number: 20210015967Abstract: A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles includes: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles.Type: ApplicationFiled: March 23, 2018Publication date: January 21, 2021Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling HO, Je-Ken CHANG, Chung-Hwan CHEN, Hui-Ting CHEN, Shun Cheng WU, Benjamin TEONG
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Patent number: 10695135Abstract: The present invention relates to a non-invasive positioning system for screwing and fixing a bone, where a intramedullary nail is inserted to marrow of the bone, and the intramedullary nail comprises a wall and at least one through-hole through the wall for screwing and fixing by at least one corresponding set screw, the system comprises: an in vitro locator having at least one light source to emit a laser with a wavelength to the muscle tissue to form an incident light and running through the muscle tissue and the bone to form a penetrated light, an optical holder having an optical lens and a positioning ring portion for removably disposing the optical lens, wherein the focusing spot of the incident light, the focusing spot of the penetrated light, and the at least one through-hole are aligned in a line to confirm a linear position for screwing and fixing the intramedullary nail.Type: GrantFiled: November 7, 2017Date of Patent: June 30, 2020Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Yin-Chih Fu, Jau-Sheng Wang, Tien-Ching Lee, Mei-Ling Ho, Wei-Chi Chen
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Patent number: 10570365Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.Type: GrantFiled: December 21, 2017Date of Patent: February 25, 2020Assignee: Kaohsiung Medical UniversityInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20200030332Abstract: The present invention relates to a use of Discoidin Domain Receptor 1 (DDR1) inhibitor in preparing a medicament for preventing or treating a joint disease. The present invention further relates to a use of DDR1 activator in preparing a medicament for preventing or treating abnormalities of endochondral ossification-related conditions.Type: ApplicationFiled: March 23, 2018Publication date: January 30, 2020Applicant: Kaohsiung Medical UniversityInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Publication number: 20200033232Abstract: Provided is a device for rapidly isolating cells from tissue, comprising: a stirring and cutting member, having a rotary cutting tool, wherein same is driven by a motor so as to rotate to stir and cut tissue, and can inject digestive enzymes to accelerate decomposition of the tissue; and double-layered nested cups comprising an inner cup and an outer cup, used for accommodating and filtering solution of required cells, wherein a filter device of the inner cup screens out the required cells, and the outer cup collects the filtered solution.Type: ApplicationFiled: September 29, 2016Publication date: January 30, 2020Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Patent number: 10278752Abstract: A bone nail apparatus includes a bone nail, a light source unit and a focalizing unit. The bone nail has a tube wall and at least one through hole. The tube wall is enclosed to form a receiving space. The at least one through hole extends through the tube wall and communicates with the receiving space. The light source unit includes a light emitter and at least one light transmission tube. The at least one light transmission tube is connected to the light emitter and receives a light therefrom. The at least one light transmission tube is received in the receiving space of the bone nail. Each light transmission tube has a light-outputting end aligned with a respective one of the at least one through hole. The focalizing unit has a light-receiving face facing one of the at least one through hole.Type: GrantFiled: October 14, 2016Date of Patent: May 7, 2019Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Jau-Sheng Wang, Tien-Ching Lee, Mei-Ling Ho, Yin-Chih Fu, Wei-Chi Chen
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Publication number: 20180354860Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.Type: ApplicationFiled: December 2, 2016Publication date: December 13, 2018Inventors: Chih-Kuang Wang, Mei-Ling Ho, Li-Cheng Pan, Yin-Chih Fu, Chung-Hwan Chen, Je-Ken Chang
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Publication number: 20180328824Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.Type: ApplicationFiled: December 21, 2017Publication date: November 15, 2018Applicant: Kaohsiung Medical UniversityInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20180298342Abstract: The present invention provides a composition for isolating adipose-derived stromal cells, which comprises a Type I collagenase of 0.5-8% (v/v); a Trypsin of 0.1-0.6% (v/v); and a metal ion chelating agent of 0.01-0.2% (v/v). The present invention further provides a method for isolating adipose-derived stromal cells, which method comprises obtaining an adipose tissue; treating the adipose tissue with the composition of the present invention; centrifuging the adipose tissue; and isolating the adipose tissue to obtain the adipose-derived stromal cells. The present invention facilitates rapid isolation of mesenchymal stromal cells within a short period of time in operating rooms and can be applied to regenerative medicine in the future.Type: ApplicationFiled: October 8, 2015Publication date: October 18, 2018Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: YAO-HSIEN WANG, CHUNG-HWAN CHEN, MEI-LING HO, JE-KEN CHANG
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Publication number: 20180169136Abstract: The present invention relates to a use of a pharmaceutical composition in the preparation of a drug for promoting chondrogenesis, wherein the pharmaceutical composition comprises a hyaluronic acid mixture and a statin compound.Type: ApplicationFiled: June 18, 2015Publication date: June 21, 2018Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-ling Ho, Je-Ken Chang, Shun-Cheng Wu, Chih-Hsiang Chang
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Publication number: 20180125587Abstract: The present invention relates to a non-invasive positioning system for screwing and fixing a bone, where a intramedullary nail is inserted to marrow of the bone, and the intramedullary nail comprises a wall and at least one through-hole through the wall for screwing and fixing by at least one corresponding set screw, the system comprises: an in vitro locator having at least one light source to emit a laser with a wavelength to the muscle tissue to form an incident light and running through the muscle tissue and the bone to form a penetrated light, an optical holder having an optical lens and a positioning ring portion for removably disposing the optical lens, wherein the focusing spot of the incident light, the focusing spot of the penetrated light, and the at least one through-hole are aligned in a line to confirm a linear position for screwing and fixing the intramedullary nail.Type: ApplicationFiled: November 7, 2017Publication date: May 10, 2018Applicants: KAOHSIUNG MEDICAL UNIVERSITY, NATIONAL SUN YAT-SEN UNIVERSITYInventors: Yin-Chih Fu, Jau-Sheng Wang, Tien-Ching Lee, Mei-Ling Ho, Wei-Chi Chen
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Patent number: 9889225Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.Type: GrantFiled: February 5, 2015Date of Patent: February 13, 2018Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling Ho, Je-Ken Chang, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Yao-Hsien Wang
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Patent number: 9775885Abstract: The present invention relates to a method for treating a bone loss disease, condition, or disorder in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a composition comprising thrombomodulin lectin-like domain (TMD1).Type: GrantFiled: January 25, 2017Date of Patent: October 3, 2017Assignee: KAOHSIUNG MEDICAL UNIVERISTYInventors: Tsung-Lin Cheng, Jwu-Lai Yeh, Mei-Ling Ho, Guey-Yueh Shi, Hua-Lin Wu
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Publication number: 20170216407Abstract: The present invention relates to a method for treating a bone loss disease, condition, or disorder in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a composition comprising thrombomodulin lectin-like domain (TMD1).Type: ApplicationFiled: January 25, 2017Publication date: August 3, 2017Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Tsung-Lin Cheng, Jwu-Lai Yeh, Mei-Ling Ho, Guey-Yueh Shi, Hua-Lin Wu