Patents by Inventor Mei-Sze Chua

Mei-Sze Chua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RADIOLABELED ANTI-GLYPICAN-3 IMMUNOCONJUGATES FROM IMMUNO-PET IMAGING OF HEPATOCELLULAR CARCINOMA
    Publication number: 20180243451
    Abstract: Provided are immunoconjugate probes useful for detecting hepatocellular carcinoma (HCC) lesions. The probes comprise a glypican-3 (GPC3)-specific monoclonal antibody or fragment thereof conjugated to a radionuclide such as 89Zr, 64Cu, and the like. The probes are useful for obtaining PET images with high tumor-to-liver ratios and targeting for diagnostic imaging of HCC lesions or cells in vitro and in vivo.
    Type: Application
    Filed: April 27, 2018
    Publication date: August 30, 2018
    Inventors: Zhen Cheng, Mei-Sze Chua, Samuel So, Xiaoyang Yang
  • RADIOLABELED ANTI-GLYPICAN-3 IMMUNOCONJUGATES FOR IMMUNO-PET IMAGING OF HEPATOCELLULAR CARCINOMA
    Publication number: 20160000946
    Abstract: Provided are immunoconjugate probes useful for detecting hepatocellular carcinoma (HCC) lesions. The probes comprise a glypican-3 (GPC3)-specific monoclonal antibody or fragment thereof conjugated to a radionuclide such as 89Zr, 64Cu, and the like. The probes are useful for obtaining PET images with high tumor-to-liver ratios and targeting for diagnostic imaging of HCC lesions or cells in vitro and in vivo.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 7, 2016
    Inventors: ZHEN CHENG, MEI-SZE CHUA, SAMUEL SO, XIAOYANG YANG
  • Methods for detecting hepatocellular carcinoma
    Patent number: 8357489
    Abstract: A method for evaluating hepatocellular carcinoma in a subject is provided. In certain embodiments, the method comprises: a) obtaining a hepatocellular carcinoma protein marker profile for a sample obtained from the subject; and b) comparing the protein marker profile to a control profile.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: January 22, 2013
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies, Inc.
    Inventors: Mei-Sze Chua, Samuel So, Hongbo Sun, Dan-Hui Dorothy Yang, Anya Tsalenko, Brian Jon Peter
  • Methods for detecting hepatocellular carcinoma
    Publication number: 20100120631
    Abstract: A method for evaluating hepatocellular carcinoma in a subject is provided. In certain embodiments, the method comprises: a) obtaining a hepatocellular carcinoma protein marker profile for a sample obtained from the subject; and b) comparing the protein marker profile to a control profile.
    Type: Application
    Filed: November 13, 2009
    Publication date: May 13, 2010
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies, Inc.
    Inventors: Mei-Sze Chua, Samuel So, Hongbo Sun, Dan-Hui Dorothy Yang, Anya Tsalenko, Brian Jon Peter
  • Substituted 2-arylbenzazole compounds and their use as antitumour agents
    Patent number: 6858633
    Abstract: Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH?Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the benzene ring of the benzazole nucleus has a halogen substituent, preferably flourine, and the 2-phenyl group has a 4?-amino substituent which may be conjugated with an amino acid to provide a water soluble amino acid amide prodrug or salt thereof.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: February 22, 2005
    Assignee: Cancer Research Technology Limited
    Inventors: Malcolm F. G. Stevens, Andrew D. Westwell, Mei-Sze Chua, Tracey D. Poole, Ian P. Hutchinson