Abstract: The present disclosure relates generally to topical delivery compositions for improved topical composition comprising at least one active agent, at least one phospholipid and urea. The active agent of the present disclosure comprises non-steroid anti-inflammatory drugs (NSAIDs). The topical delivery compositions of the present disclosure improve the solubility of the NSAIDs. The present disclosure also relates to a method for preparation of a topical composition of the present disclosure. The topical compositions are useful in treating inflammation, arthritis and/or pain, or conditions for which the signs and symptoms include inflammation, arthritis and/or pain, by topical administration to a subject.

Abstract: The present invention relates to a topical anesthetic containing anesthetic agent-clay composite as the anesthetic agent in a delivery vehicle suitable for administration to the skin for increasing anesthetic agent permeation into the skin in order to decreasing onset time. In addition, the compositions of the invention have been shown to exhibit good storage stability with low ester type of anesthetic agent decomposition even at relatively high storage temperatures.