Abstract: Methods and kits for sequencing a nucleic acid molecule are provided, which include utilizing four different compounds that are respectively derivatives of nucleotides A, (T/U), C and G, wherein the hydroxyl at the 3?-position of sugar of each of the four compounds is protected by a reversible protecting group. Each of the four compounds comprises a first linker, a second linker, and a terminal molecular label binding to or reactive to a receptor in a detectable group comprising a luminescence-activating molecule and the receptor, the luminescence-activating molecule capable of causing emission of fluorescence in the presence of a suitable substrate. The second linkers in the four compounds are different, and can be cleaved at different conditions.

Abstract: Disclosed is a process cartridge detachably mounted to an image forming device having a tray and force applying components. The process cartridge has a process cartridge frame, a photosensitive unit, a developing unit rotatable relative to the photosensitive unit. The process cartridge frame has a driving side and a conductive side disposed oppositely along a length direction. The driving side has a first driving force receiving portion for rotating a photosensitive drum and a second driving force receiving portion for rotating a developing roller. The developing unit has a force receiving portion for receiving force of force applying components to rotate the developing unit relative to the photosensitive unit. When the process cartridge is pushed into to the image forming device, the force receiving portion move at least in a left-and-right direction and/or an up-and-down direction relative to the frame of the process cartridge.

Abstract: This disclosure provides an improved filtering techniques that can provide higher sequencing accuracy for processing high-throughput sequencing data. The filtering structure uses a hierarchical network structure comprising one or more network blocks for obtaining high quality sequences. Each network block comprises a base network module (or simply a base network) and a sequence filter. The base network generates one or more sequencing quality indicators. The sequencing quality indicators can represent qualities of accuracy of the basecalling of individual bases in a sequence, the quality of one or more sequences individually, or the quality of a group of sequences as a whole. The sequence filter generates the filtered results based on the various filtering strategies based on the one or more sequencing quality indicators.

Abstract: The present disclosure describes a system for analyzing biological samples. The system includes an optical waveguide. The optical waveguide includes a first end and a second end. The optical waveguide is configured to receive an excitation light at the first end. The optical waveguide further includes a first light-guiding layer disposed between the first end and the second end. The first light-guiding layer is configured to direct, at least in part, the received excitation light toward the second end of the optical waveguide along a longitudinal direction of the optical waveguide. The optical waveguide further includes a fluidic reaction channel bounded in part by the first light-guiding layer of the optical waveguide, which delivers the excitation light to biological samples disposed in the fluidic reaction channel. The system further includes a backside illumination based image sensor.

Abstract: The present invention is directed colloidal microcrystalline compositions, particularly for suspending particles in low viscosity fluids, produced by co-attrition of a mixture of microcrystalline cellulose and a first polysaccharide in the presence of acidic attrition aid and blending a second polysaccharide; their preparation; and, products made therewith.

Abstract: Provided is a co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps that is useful for stabilizing plant protein based drinks. Also provided are plant protein drink compositions stabilized using the co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps. Also provided are methods of stabilizing plant protein drink compositions using the co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps.

Abstract: A touch panel having a visible area and a non-visible area disposed at least on one side of the visible area. The touch panel includes a substrate, a nano-metal conductive layer, a trace layer, a first passivation layer, and a second passivation layer. The nano-metal conductive layer is disposed on the substrate and at least in the visible area. The trace layer is disposed on the substrate and in the non-visible area. The trace layer is electrically connected to the nano-metal conductive layer. The first passivation layer covers the trace layer. The second passivation layer covers at least a portion of the first passivation layer. The first passivation layer has a different Young's modulus than the second passivation layer.

Abstract: Discloses herein is a storage component disassembly tooling, for disassembling a storage component on a process cartridge. The process cartridge has a housing and a storage component mounting bracket on the housing for supporting the storage component. The storage component disassembly tooling has a drilling portion and a positioning portion. The positioning portion positions the storage component disassembly tooling on the housing of the process cartridge. The drilling portion moves relative to the positioning portion to destroy at least a part of the storage component mounting bracket.

Abstract: This invention relates to making and using a stabilizer that is effective in small amounts and, particularly useful for stabilizing low solids liquids, e.g., dispersions, emulsions, and suspensions, used in foods, pharmaceuticals, nutraceuticals, and similar industrial applications, which comprises, microcrystalline cellulose, (preferably, colloidal hydrolyzed MCC); a first carboxymethyl cellulose having a viscosity of 30-85 cP at 2% in deionized water; and, a degree of carboxymethyl substitutions of 0.60 to 0.85, and a second carboxymethyl cellulose having a viscosity of 400-800 cP at 2% in deionized water, and a degree of carboxymethyl substitutions of 0.80 to 0.

Abstract: Methods and systems for determining a plurality of sequences of nucleic acid (e.g., DNA) molecules in a sequencing-by-synthesis process are provided. In one embodiment, the method comprises obtaining images of fluorescent signals obtained in a plurality of synthesis cycles. The images of fluorescent signals are associated with a plurality of different fluorescence channels. The method further comprises preprocessing the images of fluorescent signals to obtain processed images. Based on a set of the processed images, the method further comprises detecting center positions of clusters of the fluorescent signals using a trained convolutional neural network (CNN) and extracting, based on the center positions of the clusters of fluorescent signals, features from the set of the processed images to generate feature embedding vectors. The method further comprises determining, in parallel, the plurality of sequences of DNA molecules using the extracted features based on a trained attention-based neural network.

Abstract: The present disclosure describes a throughput-scalable image sensing system for analyzing biological or chemical samples is provided. The system includes a plurality of image sensors configured to detect at least a portion of light emitted as a result of analyzing the biological or chemical samples. The plurality of image sensors is arranged on a plurality of wafer-level packaged semiconductor dies of a single semiconductor wafer. Each image sensor of the plurality of image sensors is disposed on a separate packaged semiconductor die of the plurality of packaged semiconductor dies. Neighboring packaged semiconductor dies are separated by a dicing street; and the plurality of packaged semiconductor dies and a plurality of dicing streets are arranged such that the plurality of packaged semiconductor dies can be diced from the single semiconductor wafer as a group.

Abstract: A touch panel having a visible area and a non-visible area disposed at least on one side of the visible area. The touch panel includes a substrate, a nano-metal conductive layer, a trace layer, a first passivation layer, and a second passivation layer. The nano-metal conductive layer is disposed on the substrate and at least in the visible area. The trace layer is disposed on the substrate and in the non-visible area. The trace layer is electrically connected to the nano-metal conductive layer. The first passivation layer covers the trace layer. The second passivation layer covers at least a portion of the first passivation layer. The first passivation layer has a different Young's modulus than the second passivation layer.

Abstract: Discloses herein is a storage component disassembly tooling, for disassembling a storage component on a process cartridge, the process cartridge comprising a housing and a storage component mounting bracket on the housing for supporting the storage component, the storage component disassembly tooling comprising: a drilling portion, and a positioning portion; wherein the positioning portion is configured to position the storage component disassembly tooling on the housing of the process cartridge, and the drilling portion is configured to move relative to the positioning portion to destroy at least a part of the storage component mounting bracket.

Abstract: The present disclosure describes a system for analyzing biological samples. The system includes an optical waveguide. The optical waveguide includes a first end and a second end. The optical waveguide is configured to receive an excitation light at the first end. The optical waveguide further includes a first light-guiding layer disposed between the first end and the second end. The first light-guiding layer is configured to direct, at least in part, the received excitation light toward the second end of the optical waveguide along a longitudinal direction of the optical waveguide. The optical waveguide further includes a fluidic reaction channel bounded in part by the first light-guiding layer of the optical waveguide, which delivers the excitation light to biological samples disposed in the fluidic reaction channel. The system further includes a backside illumination based image sensor.

Abstract: The present disclosure describes a throughput-scalable sensing system. The system includes a plurality of semiconductor dies sharing a common semiconductor substrate and a plurality of transmembrane pore based sensors configured to detect a change of current flow as a result of analyzing biological or chemical samples. Two immediately neighboring transmembrane pore based sensors are arranged on respective two semiconductor dies separated by a dicing street. Each transmembrane pore based sensor is arranged on a separate semiconductor die of the plurality of semiconductor dies. At least one transmembrane pore based sensor includes one or more detection electrodes disposed above the common semiconductor substrate and a lipid bilayer disposed above the one or more detection electrodes.

Abstract: A biosensor for detecting light signals emitted by a biological material is provided. The biosensor includes a light signal detector which comprises an array of light sensor pixels. The biosensor further includes a light signal filter layer disposed on a surface of the light sensor pixel array, a metal nanometer light focusing unit array layer, a grating array layer which comprises micro-gratings, and a biological material sample bearing area which comprises a plurality of sample gathering units. Each sample gathering unit aligns with one micro-grating and one metal nanometer light focusing unit in the vertical direction, and at least one of the light sensor pixels.

Abstract: The present disclosure describes a throughput-scalable photon sensing system. The system includes a plurality of semiconductor dies sharing a common semiconductor substrate and a plurality of photon detection sensors configured to perform a single molecule analysis of biological or chemical samples. Two immediately neighboring photon detection sensors are arranged on respective two semiconductor dies separated by a dicing street. Each photon detection sensor is arranged on a separate semiconductor die. The system further includes a first optical waveguide, a plurality of second optical waveguides disposed above the first optical waveguide, one or more wells disposed in the plurality of second optical waveguides, and one or more light guiding channels.