Publication number: 20040014053
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
August 1, 2002
Publication date:
January 22, 2004
Inventors:
Bryan D. Zerhusen, Meera Patturajan, Ramesh Kekuda, Charles E. Miller, Daniel K. Rieger, Carol E.A. Pena, Richard A. Shimkets, Li Li, Constance Berghs, Mei Zhong, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Muralidhara Padigaru, Glennda Smithson, Weizhen Ji, Linda Gorman, Corine A.M. Vernet, Mario W. Leite, Xiaojia Sasha Guo, David W. Anderson, Kimberly A. Spytek, Valerie Gerlach, Catherine E. Burgess, Nikolai V. Khramtsov, Tatiana Ort, Karen Ellerman, Luca Rastelli, Michele L. Agee, Amitabha Chaudhuri, John S. Chant, Vincent A. DiPippo, Shlomit R. Edinger, Andrew J. Eisen, Esha A. Gangolli, Loic Giot, Chean Eng Ooi, Mark E. Rothenberg, Steven K. Spaderna, Tord Hjalt, Xiaohong Liu, Raymond J. Taupier, Elina Catterton, Suresh G. Shenoy
Publication number: 20040014058
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
October 1, 2002
Publication date:
January 22, 2004
Inventors:
John P. Alsobrook, Catherine E. Burgess, Elina Catterton, John S. Chant, Ammitabha Chaudhuri, Shlomit Edinger, Valerie Gerlach, Loic Giot, Linda Gorman, Xiaojia (Sasha) Guo, Ramesh Kekuda, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Meera Patturajan, Daniel K. Rieger, Kimberly A. Spytek, Raymond J. Taupier, Bryan D. Zerhusen, Haihong Zhong, Mei Zhong
Publication number: 20040006205
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
April 2, 2002
Publication date:
January 8, 2004
Inventors:
Li Li, Valerie Gerlach, Xiaohong Liu, Charles E. Miller, Kimberly A. Spytek, Bryan D. Zerhusen, Carol E. A. Pena, Suresh G. Shenoy, Haihong Zhong, Glennda Smithson, Stacie J. Casman, Ferenc L. Boldog, Edward Z. Voss, Corine A. Vernet, John R. MacDougall, Luca Rastelli, David W. Anderson, Mei Zhong, Peter S. Mezes, Katarzyna Furtak, Meera Patturajan, Catherine E. Burgess, Uriel M. Malyankar, Richard A. Shimkets, Raymond J. Taupier, Schlomit Edinger, Ann Mazur
Publication number: 20040002120
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
March 7, 2002
Publication date:
January 1, 2004
Inventors:
Ramesh Kekuda, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Meera Patturajan, Catherine E. Burgess, Corine A.M. Vernet, Li Li, Linda Gorman, Uriel M. Malyankar, Ferenc L. Boldog, Xiaojia (Sasha) Guo, Suresh G. Shenoy, Muralidhara Padigaru, Raymond J. Taupier, Charles E. Miller, Stacie J. Casman, Carol E. A. Pena, Esha A. Gangolli, Vladimir Y. Gusev, Glennda Smithson, Bryan D. Zerhusen, Valerie Gerlach, Pascale F-J Pochart, Elma R. Fernandes, Richard A. Shimkets, Luca Rastelli, Steven K. Spaderna, William J. LaRochelle, Mei Zhong, Nikolai V. Khramtsov, Edward Z. Voss, John L. Herrmann
Publication number: 20030232347
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
August 1, 2002
Publication date:
December 18, 2003
Inventors:
David W. Anderson, John P. Alsobrook, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Linda Gorman, Xiaojia Sasha Guo, Nikolai V. Khramtsov, Denise M. Lepley, John R. MacDougall, Carol E. A. Pena, John A. Peyman, Meera Patturajan, Daniel K. Rieger, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
Publication number: 20030229016
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
December 2, 2002
Publication date:
December 11, 2003
Inventors:
John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Shlomit R. Edinger, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Li Li, Meera Patturajan, Daniel K. Rieger, Suresh G. Shenoy, Kimberly A. Spytek, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
Publication number: 20030224982
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
July 2, 2002
Publication date:
December 4, 2003
Inventors:
Li Li, Suresh G. Shenoy, Meera Patturajan, Karen Ellerman, Linda Gorman, Mei Zhong, Elina Catterton, Kimberly A. Spytek, Charles E. Miller, Shlomit R. Edinger, Tord Hjalt, Valerie Gerlach, Richard A. Shimkets, Raymond J. Taupier, David W. Anderson, Xiaojia (Sasha) Guo, Jason C. Baumgartner, Muralidhara Padigaru, John A. Peyman, Glennda Smithson, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Carol E. A. Pena, Andrei Chapoval, Luca Rastelli, Ramesh Kekuda, Corine A.M. Vernet
Publication number: 20030208039
Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
Type:
Application
Filed:
March 8, 2002
Publication date:
November 6, 2003
Inventors:
Muralidhara Padigaru, Suresh G. Shenoy, Remesh Kekuda, Vladimir Gusev, Pascale F-J Pochart, Mei Zhong, Luca Rastelli, Peter D. Mezes, Glennda Smithson, Xiaojia Sasha Guo, Valerie Gerlach, Stacie J. Casman, Ferenc L. Boldog, Li Li, Bryan D. Zerhusen, Velizar T. Tchernev, Esha A. Gangolli, Corine A.M. Vernet, Carol E. A. Pena, Catherine E. Burgess, Xiaohong Liu, Kimberly A. Spytek, Linda Gorman, Steven K. Spaderna, Edward Z. Voss, Uriel M. Malyankar, David W. Anderson, Meera Patturajan, Charles E. Miller, Raymond J. Taupier