Patents by Inventor Meidong Yang

Meidong Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20220331261
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: March 17, 2022
    Publication date: October 20, 2022
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 11331278
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 17, 2022
    Assignee: DFB SORIA, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20210106539
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: December 4, 2020
    Publication date: April 15, 2021
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10918606
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 16, 2021
    Assignee: DFB Soria, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20200069600
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 5, 2020
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10449162
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: October 22, 2019
    Assignee: DFB Soria LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20180177739
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 28, 2018
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • PHARMACEUTICAL COMPOSITIONS OF SPIRO-OXINDOLE COMPOUND FOR TOPICAL ADMINISTRATION AND THEIR USE AS THERAPEUTIC AGENTS
    Publication number: 20170095449
    Abstract: This invention is directed to pharmaceutical compositions for topical administration to a mammal, wherein the pharmaceutical compositions comprise a spiro-oxindole compound, as an enantiomer, a racemate or a non-racemic mixture, or a pharmaceutically acceptable salt thereof. These pharmaceutical compositions are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions.
    Type: Application
    Filed: October 11, 2016
    Publication date: April 6, 2017
    Inventors: Conrad Stewart Winters, Meidong Yang, Haigang Chen
  • Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
    Patent number: 9504671
    Abstract: This invention is directed to pharmaceutical compositions for topical administration to a mammal, wherein the pharmaceutical compositions comprise a spiro-oxindole compound, as an enantiomer, a racemate or a non-racemic mixture, or a pharmaceutically acceptable salt thereof. These pharmaceutical compositions are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: November 29, 2016
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Conrad Stewart Winters, Meidong Yang, Haigang Chen
  • METHODS AND COMPOSITIONS FOR INCREASING SOLUBILITY OF AZOLE DRUG COMPOUNDS THAT ARE POORLY SOLUBLE IN WATER
    Publication number: 20150196536
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Application
    Filed: September 25, 2014
    Publication date: July 16, 2015
    Inventors: Meidong Yang, Haigang Chen
  • Compositions for increasing solubility of azole drug compounds that are poorly soluble in water
    Patent number: 8877792
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: November 4, 2014
    Assignee: Dow Pharmaceutical Sciences, Inc.
    Inventors: Meidong Yang, Haigang Chen
  • Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water
    Patent number: 8658678
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: February 25, 2014
    Assignee: Dow Pharmaceutical Sciences, Inc.
    Inventors: Meidong Yang, Haigang Chen
  • PHARMACEUTICAL COMPOSITIONS OF SPIRO-OXINDOLE COMPOUND FOR TOPICAL ADMINISTRATION AND THEIR USE AS THERAPEUTIC AGENTS
    Publication number: 20130143941
    Abstract: This invention is directed to pharmaceutical compositions for topical administration to a mammal, wherein the pharmaceutical compositions comprise a spiro-oxindole compound, as an enantiomer, a racemate or a non-racemic mixture, or a pharmaceutically acceptable salt thereof. These pharmaceutical compositions are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions.
    Type: Application
    Filed: February 25, 2011
    Publication date: June 6, 2013
    Inventors: Conrad Stewart Winters, Meidong Yang, Haigang Chen
  • COMBINATION OF DAPSONE WITH OTHER ANTI-ACNE AGENTS
    Publication number: 20110305747
    Abstract: A composition suitable for topical application that contains at least two active ingredients, one of these being dapsone and one selected from the group consisting of adapalene, tazarotene and treinion for the effective treatment of acne and other dermatological conditions.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 15, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Gurpreet Ahluwalia, Kevin S. Warner, Haigang Chen, Meidong Yang, Jeffrey R. Ehrhardt, Frederick C. Beddingfield
  • COMBINATION OF DAPSONE WITH OTHER ANTI-ACNE AGENTS
    Publication number: 20110117182
    Abstract: A composition suitable for topical application that contains at least two active ingredients, one of these being dapsone and one selected from the group consisting of adapalene, tazarotene and treinion for the effective treatment of acne and other dermatological conditions.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 19, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Gurpreet Ahluwalia, Kevin S. Warner, Haigang Chen, Meidong Yang
  • Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water
    Publication number: 20110082179
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Application
    Filed: December 8, 2010
    Publication date: April 7, 2011
    Inventors: Meidong Yang, Haigang Chen
  • Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water
    Patent number: 7893097
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Grant
    Filed: February 2, 2008
    Date of Patent: February 22, 2011
    Assignee: Dow Pharmaceutical Sciences, Inc.
    Inventors: Meidong Yang, Haigang Chen
  • Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water
    Publication number: 20090197896
    Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
    Type: Application
    Filed: February 2, 2008
    Publication date: August 6, 2009
    Inventors: Meidong Yang, Haigang Chen
  • Topical formulations of borinic acid antibiotics and their methods of use
    Publication number: 20060217347
    Abstract: Disclosed are topical formulations, for example, creams, gels, or lotions, of borinic acid antibiotic compounds active against acne vulgaris or secondarily infected skin conditions.
    Type: Application
    Filed: March 24, 2006
    Publication date: September 28, 2006
    Inventors: David Perry, Kirk Maples, Meidong Yang
  • Skin and hair cleansers containing sulfur
    Publication number: 20040259744
    Abstract: A sulfur-containing cleanser formulation containing a surfactant and a lipophilic emulsifying agent at a concentration of 7 w/w % or greater. The cleanser formulation has reduced sulfur malodor compared to a similar formulation with a concentration of lipophilic emulsifying agent less than 7 w/w %.
    Type: Application
    Filed: December 19, 2003
    Publication date: December 23, 2004
    Inventors: Meidong Yang, Gordon J. Dow