Patents by Inventor Meijie HUANG

Meijie HUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease
    Patent number: 10807957
    Abstract: A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.
    Type: Grant
    Filed: November 24, 2018
    Date of Patent: October 20, 2020
    Inventors: Yan Liu, Xingguo Liu, Weixin Zhang, Daya Huang, Meijie Huang, Dean Wang, Ju Huang, Siwei Shu, Michel Nguyen, Anne Robert, Bernard Meunier
  • TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE
    Publication number: 20190092730
    Abstract: A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.
    Type: Application
    Filed: November 24, 2018
    Publication date: March 28, 2019
    Inventors: Yan LIU, Xingguo LIU, Weixin ZHANG, Daya HUANG, Meijie HUANG, Dean WANG, Ju HUANG, Siwei SHU, Michel NGUTEN, Anne ROBERT, Bernard MEUNIER