Abstract: The invention discloses a 4-(N-methyl) aminopiperidine myricetin derivatives containing sulfonamide, a preparation method and application, whose structural general formula is shown as follows: Wherein, R is substituted phenyl and substituted aromatic heterocyclic group; n is the number of carbon in the carbon chain and is 2, 3, 4 and 5 respectively. The substituted phenyl group is an alkyl group containing C1-6, an alkoxy group containing C1-6, a nitro group, a halogen atom or a hydrogen atom in ortho, meta and para positions on the benzene ring. The substituted aromatic heterocyclic group is thienyl, furyl, pyrrolyl, pyridyl, etc., and the substituent on the aromatic heterocyclic ring is an alkyl group containing C1-6, alkoxy group of C1-6, nitro group, halogen atom or hydrogen atom in ortho, meta and para positions. The invention has a better control effect on inhibiting plant germs and can be used as an agricultural bactericide.