Patents by Inventor Meina Lin

Meina Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200147262
    Abstract: The present invention discloses polyglycol epoxide crosslinked sodium hyaluronate gel for injection and a preparation method thereof. A polyglycol epoxide is a compound with single molecular weight preferably; a plurality of ether bonds are present in the molecule of the polyglycol epoxide, the water solubility is good, and thus, the polyglycol epoxide is more easily subjected to a crosslinking reaction with polysaccharides; and meanwhile, polyglycol is relatively easy in adjustment of the number of repeating units and relatively easy in control of length, and thus, the sodium hyaluronate gel prepared by taking the polyglycol epoxide as a crosslinker is relatively easy in regulation and control of properties. The crosslinked sodium hyaluronate gel is low in toxicity, little in residual, small in squeezing and pushing force, good in shaping performance, good in enzyme resistance and long in in-vivo retention time. The present invention further discloses a mild crosslinker deactivation technology.
    Type: Application
    Filed: December 26, 2017
    Publication date: May 14, 2020
    Applicant: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
    Inventors: Zhen WEI, Meina LIN, Xuan ZHAO
  • Publication number: 20200129542
    Abstract: The present invention discloses a branched polyethylene glycol epoxy derivative crosslinked sodium hyaluronate gel, preparation and application thereof. The crosslinking agent used in the crosslinked sodium hyaluronate gel prepared by the present invention is a polyethylene glycol epoxy derivative, due to the existence of multiple ether bonds in the molecule of the crosslinking agent, there are more hydrogen bonds in the gel system; meanwhile, due to the particularity of the space structure of the branched polyethylene glycol epoxy derivative, the gel prepared has a more complex winding structure in its space, thus achieving better stability. Moreover, the branched polyethylene glycol epoxy derivative involved in the present invention is a compound with single molecular weight, therefore, the gel prepared thereby has better batch stability.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: ZHEN WEI, MEINA LIN, XUAN ZHAO
  • Publication number: 20200131109
    Abstract: Being used for drug modification, the multi-arm single molecular weight polyethylene glycol and an active derivative thereof provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the active derivative of the multi-arm single molecular weight polyethylene glycol provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: ZHEN WEI, MEINA LIN, XUAN ZHAO
  • Publication number: 20200131147
    Abstract: The present invention discloses a PEGylated thioxanthone photoinitiator and a photosensitive resin composition, the PEGylated thioxanthone compound is eco-friendly and has low toxicity, high initiation efficiency and good thermal stability, meanwhile, as a kind of photoinitiator, the compound has a small amount of fragment residue after cured, and may improve the compatibility of the photoinitiator and photosensitive resin composition system. The photosensitive resin composition provided by the present invention has reasonable allocation of ingredients and content in the components thereof, capable of 3D-printing a hydrogel having a specific structure; the hydrogel has lower cytotoxicity and better biocompatibility, and may applied in bioengineering fields, e.g., 3D cell culture.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: HUI ZHU, MEINA LIN, XUAN ZHAO
  • Publication number: 20200131107
    Abstract: The disclosure discloses a dendritic polyethylene glycol derivative and a preparation method and an application thereof. The dendritic polyethylene glycol derivative has a structure of formula (I), has multiple end functional groups, has a stronger water solubility in comparison with linear-chain polyethylene glycol, and can solve a problem of insufficient water solubility due to the increase of load when modifying an insoluble drug by the polyethylene glycol. The preparation method of the dendritic polyethylene glycol derivative provided by the disclosure has mild reaction conditions, is green and environmentally friendly, is low in cost, and is easy to implement industrialization.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: HUI ZHU, MEINA LIN, XUAN ZHAO
  • Publication number: 20200136194
    Abstract: An electrode assembly and a lithium ion electric roll having the same are provided. Also provided is a battery, which includes: a first layer; a second layer located at the side of a surface of the first layer, exposed from the first layer in a first direction view which is perpendicular to a first surface of the first layer; a third layer tucking at least one portion of the second layer with the first layer in the first direction view, being exposed from the second layer in the first direction view; and a conductive plate protruding from a second side of the first layer in the first direction view.
    Type: Application
    Filed: January 2, 2020
    Publication date: April 30, 2020
    Inventors: Junliang Zhu, Haibing Wang, Tongming Dong, Wenqiang Cheng, Baohua Chen, Shufeng Wu, Wei Yang, Zhihua Qin, Meina Lin
  • Publication number: 20200046842
    Abstract: The present invention provides a multi-drug-loading site and high drug-loading capacity ligand-drug conjugate. The ligand-drug conjugate has a structure of general formula (I). The ligand-drug conjugate has the characteristics of high loading capacity, high drug efficacy, low toxicity, and low risks. The ligand-drug conjugate can be used particularly to connect to a low toxicity chemical molecule, thereby extending a therapeutic window. Furthermore, the present invention provides an antibody-drug conjugate molecule. The antibody-drug conjugate molecule has the characteristics of multiple drug-loading ability and high drug-loading capacity, such that the antibody-drug conjugate can carry a large amount of a low toxicity chemical molecule and achieve a therapeutic effect without depending on antibody targeting or high toxicity chemicals.
    Type: Application
    Filed: September 30, 2019
    Publication date: February 13, 2020
    Inventors: Yanping SONG, Jinghui DU, Leimin WANG, Jinliang WANG, Meina LIN, Zewang FENG, Xuan ZHAO
  • Publication number: 20200024446
    Abstract: Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product of the reaction is easy to be separated, the cost for separation is low, and the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, which is advantageous for industrial scale-up and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular in the use of the preparation of medicaments for preventing and/or treating diseases.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 23, 2020
    Inventors: Xiaomeng CHEN, Meina LIN, Rujun ZHANG, Xuan ZHAO
  • Publication number: 20200024374
    Abstract: The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 23, 2020
    Inventors: Hui ZHU, Meina LIN, Zhen WEI, Xuan ZHAO
  • Patent number: 10525143
    Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 7, 2020
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Jinliang Wang, Zewang Feng, Hui Zhu, Meina Lin, Yan Liu, Xuan Zhao
  • Patent number: 10464882
    Abstract: The present invention discloses a Y-type discrete polyethylene glycol derivative, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: November 5, 2019
    Assignee: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
    Inventors: Hui Zhu, Meina Lin, Xiaomeng Chen, Zhen'gang Zhu, Xuan Zhao
  • Patent number: 10283816
    Abstract: The present application relates to the filed of an energy storage component, and in particular, relates to an electrode assembly, and a lithium ion electric roll using the electrode assembly. The electrode assembly comprises a bare electric roll and an anti-puncture cushion; wherein the bare electric roll comprises at least one electrode unit, the electrode unit comprising a cathode sheet, an anode sheet, and a separator, wherein the cathode sheet is isolated from the anode sheet by the separator; and the anti-puncture cushion is arranged on two sides along a width direction of the bare electric roll, and covers an edge of the anode sheet. A lithium ion electric roll comprises a laminated aluminum film and the electrode assembly, wherein the electrode assembly is wrapped by the laminated aluminum film.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 7, 2019
    Assignee: DONGGUAN AMPEREX TECHNOLOGY LIMITED
    Inventors: Junliang Zhu, Haibing Wang, Tongming Dong, Wenqiang Cheng, Baohua Chen, Shufeng Wu, Wei Yang, Zhihua Qin, Meina Lin
  • Patent number: 10280259
    Abstract: The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the derivative, X1, X2, X3 and X4 are linking groups, F1, F2, F3 and F4 are end groups, the end groups may be the same or may also be different, and are selected from: hydroxy, carboxyl, ester group, amino, alkynyl or the like, at least one of the end groups is alkynyl, and PEG is the same or different —(CH2CH2O)m—, wherein m is an integer ranging from 3 to 250, and l is an integer greater than or equal to 1. The multi-arm polyethylene glycol derivatives have stronger application flexibility, and have good application prospect in aspects such as organic synthesis, medicine synthesis and medical instruments.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 7, 2019
    Assignee: JENKEM TECHNOLOGY CO., LTD.
    Inventors: Meina Lin, Xiaomeng Chen
  • Publication number: 20190117790
    Abstract: A PEG linker as represented by formula (I), wherein n and m are respectively an integer from 1 to 7, providing the PEG linker with 1 to 49 linking sites. A ligand drug conjugate as represented by formula (II). The conjugate uses the PEG linker to increase a drug loading capacity and drug loading diversity, thereby improving pharmaceutical efficacy.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 25, 2019
    Inventors: Yanping SONG, Wen LI, Jinliang WANG, Yan LIU, Kun ZHENG, Meina LIN, Zhen WEI, Zewang FENG, Xuan ZHAO
  • Publication number: 20190016856
    Abstract: Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using the same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or not the same —(OCH2CH2)m—, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.
    Type: Application
    Filed: September 17, 2018
    Publication date: January 17, 2019
    Inventors: Zhen WEI, Meina LIN, Zhengang ZHU, Xuan ZHAO
  • Publication number: 20180375160
    Abstract: An electrode assembly and a lithium ion electric roll having the same are provided. The electrode assembly includes: a first electrode unit; a first anti-puncture cushion; in which the first electrode unit includes a first electrode sheet, an second electrode sheet, and a separator, the separator is disposed between the first electrode sheet and the second electrode sheet; the first anti-puncture cushion is disposed on a side of the first electrode unit along a width direction, and covers an edge of the first electrode sheet.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 27, 2018
    Inventors: Junliang ZHU, Haibing Wang, Tongming Dong, Wenqiang Cheng, Baohua Chen, Shufeng Wu, Wei Yang, Zhihua Qin, Meina Lin
  • Publication number: 20180362712
    Abstract: Disclosed is a Y-type discrete polyethylene glycol derivative as shown by Formula (I). The Y-type discrete polyethylene glycol derivative has the advantages of a determined molecular weight and number of segments in the chain, and can avoid the defects where the polyethylene glycol derivative itself is a mixture and the molecular weight is not homogeneous. The Y-type polyethylene glycol of the present invention can solve the problem of insufficient water solubility caused by an increase in the loading capacity when the discrete polyethylene glycol modifies an insoluble drug while increasing the drug loading capacity.
    Type: Application
    Filed: June 21, 2018
    Publication date: December 20, 2018
    Inventors: Hui ZHU, Meina LIN, Xuan ZHAO
  • Patent number: 10039837
    Abstract: Provided is a multi-arm polyethylene glycol-azido derivative of general formula I, wherein R is a central molecule, which is selected from a polyhydroxy structure, a polyamino structure or a polycarboxyl structure; n is the number of branches or arms, n?3; PEG is the same or different —(CH2CH2O)m—, the average value of m being an integer from 3 to 250; X is a linking group of a azido end group; k is the number of the branches having the azido end group; F is selected from the group consisting of amino, carboxyl, sulfhydryl, ester group, maleic imide group and acrylic group; and Y is a linking group of an end group F.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: August 7, 2018
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Xiaomeng Chen, Meina Lin, Xuan Zhao
  • Publication number: 20180110867
    Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 26, 2018
    Inventors: Jinliang Wang, Zewang Feng, Hui Zhu, Meina Lin, Yan Liu, Xuan Zhao
  • Publication number: 20180044280
    Abstract: The present invention discloses a Y-type discrete polyethylene glycol derivative and a preparation method thereof, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative, meanwhile the preparation method has simple steps, mild conditions, without need for strictly anhydrous environment or performing protection and deprotection steps. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Inventors: Hui ZHU, Meina LIN, Xiaomeng CHEN, Zhen'gang ZHU, Xuan ZHAO