Patents by Inventor Meinolf Thiemann

Meinolf Thiemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition comprising a mixture of CD95-Fc isoforms
    Patent number: 9657083
    Abstract: The present invention relates to a composition comprising a mixture of fusion protein isoforms, each fusion protein comprising an extracellular CD95 domain or a functional fragment thereof or an Fc domain or functional fragment thereof, formulations providing such composition in a stable form as well as a method for producing such a composition.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 23, 2017
    Assignee: Apogenix AG
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • GITRL COLLECTIN FUSION PROTEINS
    Publication number: 20170081386
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: December 2, 2016
    Publication date: March 23, 2017
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN, Marcus BRANSCHÄDEL
  • SINGLE-CHAIN FUSION POLYPEPTIDE COMPRISING TRAIL
    Publication number: 20170081381
    Abstract: The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: December 5, 2016
    Publication date: March 23, 2017
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN
  • CD40L collectin fusion proteins and encoding nucleic acid molecules
    Patent number: 9527897
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: December 27, 2016
    Assignee: Apogenix AG
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann, Marcus Branschädel
  • SHORTENED CD95-FC VARIANTS
    Publication number: 20160362471
    Abstract: The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or functional fragment thereof, formulations providing such fusion protein in a stable form as well as a method for producing such a fusion protein.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 15, 2016
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN
  • Fusion proteins forming trimers
    Patent number: 9469681
    Abstract: The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: October 18, 2016
    Assignee: APOGENIX AG
    Inventors: Oliver Hill, Marcus Branschaedel, Christian Gieffers, Meinolf Thiemann
  • CD27 SINGLE CHAIN MOLECULES
    Publication number: 20160272695
    Abstract: The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 22, 2016
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN
  • Shortened CD95-Fc variant fusion proteins, nucleic acids and host cells thereof
    Patent number: 9434783
    Abstract: The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or functional fragment thereof, formulations providing such fusion protein in a stable form as well as a method for producing such a fusion protein.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: September 6, 2016
    Assignee: APOGENIX AG
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • COMPOSITION COMPRISING A MIXTURE OF CD95-FC ISOFORMS
    Publication number: 20160235815
    Abstract: The present invention relates to a composition comprising a mixture of fusion protein isoforms, each fusion protein comprising an extracellular CD95 domain or a functional fragment thereof or an Fc domain or functional fragment thereof, formulations providing such composition in a stable form as well as a method for producing such a composition.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 18, 2016
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN
  • CD40L COLLECTIN FUSION PROTEINS
    Publication number: 20160176941
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 23, 2016
    Inventors: Oliver HILL, Christian GIEFFERS, Meinolf THIEMANN, Marcus BRANSCHÄDEL
  • Single chain trail fusion polypeptides and encoding nucleic acids
    Patent number: 9359420
    Abstract: The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 7, 2016
    Assignee: APOGENIX AG
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • Single chain CD40L fusion polypeptides
    Patent number: 9340599
    Abstract: The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: May 17, 2016
    Assignee: APOGENIX AG
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • Composition comprising a mixture of CD95-Fc isoforms and methods of producing same
    Patent number: 9315570
    Abstract: The present invention relates to a composition comprising a mixture of fusion protein isoforms, each fusion protein comprising an extracellular CD95 domain or a functional fragment thereof or an Fc domain or functional fragment thereof, formulations providing such composition in a stable form as well as a method for producing such a composition.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: April 19, 2016
    Assignee: APOGENIX GMBH
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • Trail collectin fusion proteins
    Patent number: 9212211
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: December 15, 2015
    Assignee: APOGENIX GMBH
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann, Marcus Branschädel
  • SINGLE-CHAIN TRAIL-RECEPTOR AGONIST PROTEINS
    Publication number: 20150337027
    Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: April 23, 2015
    Publication date: November 26, 2015
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann, Fritz G. Buchanan, Darren C. Phillips, Susan E. Lappe
  • COMPOSITION COMPRISING A MIXTURE OF CD95-FC ISOFORMS
    Publication number: 20150225475
    Abstract: The present invention relates to a composition comprising a mixture of fusion protein isoforms, each fusion protein comprising an extracellular CD95 domain or a functional fragment thereof or an Fc domain or functional fragment thereof, formulations providing such composition in a stable form as well as a method for producing such a composition.
    Type: Application
    Filed: July 18, 2013
    Publication date: August 13, 2015
    Applicant: Apogenix GmbH
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • SHORTENED CD95-FC VARIANTS
    Publication number: 20150166633
    Abstract: The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or functional fragment thereof, formulations providing such fusion protein in a stable form as well as a method for producing such a fusion protein.
    Type: Application
    Filed: July 18, 2013
    Publication date: June 18, 2015
    Applicant: Apogenix GmbH
    Inventors: Oliver Hill, Christian Gieffers, Meinolf Thiemann
  • TRAIL SINGLE CHAIN MOLECULES
    Publication number: 20150125419
    Abstract: The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: June 30, 2014
    Publication date: May 7, 2015
    Inventors: Oliver HILL, Christian Gieffers, Meinolf Thiemann
  • TRAIL COLLECTIN FUSION PROTEINS
    Publication number: 20150126709
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 7, 2015
    Inventors: Oliver HILL, Christian Gieffers, Meinolf Thiemann, Marcus Branschädel
  • FUSION PROTEINS FORMING TRIMERS
    Publication number: 20150126710
    Abstract: The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 7, 2015
    Inventors: Oliver HILL, Marcus Branschädel, Christian Gieffers, Meinolf Thiemann