Patents by Inventor Meir Bialer

Meir Bialer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTICONVULSANT CARBAMATE DERIVATIVES
    Publication number: 20180339963
    Abstract: The invention contemplates novel materials as anticonvulsant agents.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir BIALER, David BIBI, Hafiz MAWASI
  • COMPOSITIONS AND METHODS OF TREATMENT OF STATUS EPILEPTICUS
    Publication number: 20150038588
    Abstract: The invention provides a method of treating benzodiazepine-resistant status epilepticus in a subject having been exposed to a nerve agent inducing the status epilepticus.
    Type: Application
    Filed: March 6, 2013
    Publication date: February 5, 2015
    Inventors: Meir Bialer, Boris Yagen
  • Acyl-urea derivatives and uses thereof
    Patent number: 8846903
    Abstract: Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: September 30, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir Bialer, Boris Yagen, Jakob Avi Shimshoni
  • Amide derivatives of valproic acid and uses thereof
    Patent number: 8829242
    Abstract: Amide derivatives of valproic acid are provided along their use in the treatment of epilepsy.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: September 9, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Meir Bialer, Boris Yagen, Dan Kaufmann, Marshall Devor
  • Alpha-halo- and alpha-alkyl-cyclopropylcarboxy compounds and uses thereof
    Patent number: 8518979
    Abstract: Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: August 27, 2013
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir Bialer, Boris Yagen, Neta Pessah
  • Compounds useful for treating bipolar disorders
    Patent number: 8399708
    Abstract: The invention relates to the use of valnoctamide (VCD) for the treatment of bipolar disorder and in particular for the treatment of the manic phase of the bipolar disorder.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: March 19, 2013
    Assignee: Yissum Research Developmemt Company of the Hebrew University of Jerusalem
    Inventors: Meir Bialer, Boris Yagen
  • SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM
    Publication number: 20120264827
    Abstract: The present invention concerns a family of sulfanilamide derivatives of formula (I) as anticonvulsant agents, where R is selected from optionally substituted C4-C9 alkyl, optionally substituted C6-C10 aryl, optionally substituted C6-C10 alkylenearyl and optionally substituted C5-C10heteroaryl; R2 is selected from —H and optionally substituted C1-C6 alkyl; each of R3 and R4, independently of each other, is selected from —H, optionally substituted C1-C6 alkyl, optionally substituted C6-C10 aryl and optionally substituted C5-C10 heteroaryl; n is 0, 1, 2, 3 or 4. The derivatives have been prepared and their anticonvulsant profile was evaluated for the control of epileptic seizures.
    Type: Application
    Filed: September 21, 2010
    Publication date: October 18, 2012
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Meir Bialer, Boris Yagen, Hen Naama
  • Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders
    Patent number: 8288442
    Abstract: A method for the treatment or prevention of pain and/or a headache disorder using a derivative of a valproic acid amide or a 2-valproenic acid amide, as well as pharmaceutical compositions comprising these derivatives or compounds.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: October 16, 2012
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Mitchell Shirvan, Meir Bialer
  • AMIDE DERIVATIVES OF VALPROIC ACID AND USES THEREOF
    Publication number: 20120184623
    Abstract: Amide derivatives of valproic acid are provided along their use in the treatment of epilepsy.
    Type: Application
    Filed: September 21, 2010
    Publication date: July 19, 2012
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LT.D
    Inventors: Meir Bialer, Boris Yagen, Dan Kaufmann, Marshall Devor
  • ACYL-UREA DERIVATIVES AND USES THEREOF
    Publication number: 20100280124
    Abstract: Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.
    Type: Application
    Filed: June 25, 2008
    Publication date: November 4, 2010
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir Bialer, Boris Yagen, Jakob Avi Shimshoni
  • COMPOUNDS USEFUL FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20100160443
    Abstract: The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.
    Type: Application
    Filed: March 2, 2010
    Publication date: June 24, 2010
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Meir Bialer, Boris Yagen, Ilan Winkler, Marshall Devor
  • ALPHA-HALO- AND ALPHA-ALKYL-CYCLOPROPYLCARBOXY COMPOUNDS AND USES THEREOF
    Publication number: 20100152254
    Abstract: Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided.
    Type: Application
    Filed: February 19, 2008
    Publication date: June 17, 2010
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir Bialer, Boris Yagen, Neta Pessah
  • COMPOUNDS USEFUL FOR TREATING BIPOLAR DISORDERS
    Publication number: 20100056827
    Abstract: The invention relates to the use of valnoctamide (VCD) for the treatment of bipolar disorder and in particular for the treatment of the manic phase of the bipolar disorder.
    Type: Application
    Filed: June 15, 2006
    Publication date: March 4, 2010
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Meir Bialer, Boris Yagen
  • USE OF 2,2,3,3, TETRAMETHYLCYCLOPROPANE CARBOXYLIC ACID DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS
    Publication number: 20100048721
    Abstract: The invention relates to the use of 2,2,3,3 tetramethylcyclopropane carboxylic acid derivative compounds for the preparation of a medicament for treating a psychiatric disorder preferably a bipolar disorder. The invention additionally relates to the use of the compounds for the preparation of an inhibitor of MIP synthase and to a pharmaceutical composition comprising the compounds for treating a psychiatric disorder. A method for treating a psychiatric disorder preferably a bipolar disorder and a method for inhibiting an enzyme having MIP synthase activity is provided.
    Type: Application
    Filed: May 27, 2004
    Publication date: February 25, 2010
    Applicants: Yissum Research Development Co. of the Hebrew University of Jerusalem, Ben Gurion University of the Negev Research and Development Authority
    Inventors: Meir BIALER, Boris YAGEN, Haim BELMAKER, Galila AGAM, Galit SHALTIEL
  • Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders
    Publication number: 20090281045
    Abstract: A method for the treatment or prevention of pain and/or a headache disorder using a derivative of a valproic acid amide or a 2-valproenic acid amide, as well as pharmaceutical compositions comprising these derivatives or compounds.
    Type: Application
    Filed: June 24, 2009
    Publication date: November 12, 2009
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Mitchell Shirvan, Meir Bialer
  • Compounds Useful For Treating Neurological Disorders
    Publication number: 20090182048
    Abstract: The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.
    Type: Application
    Filed: March 20, 2009
    Publication date: July 16, 2009
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Meir BIALER, Boris YAGEN, IIan WINKLER, Marshall DEVOR
  • COMPOUNDS USEFUL FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20080139651
    Abstract: The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.
    Type: Application
    Filed: October 10, 2007
    Publication date: June 12, 2008
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Meir BIALER, Boris YAGEN, Ilan WINKLER, Marshall DEVOR
  • COMPOUNDS USEFUL FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20080081839
    Abstract: The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 3, 2008
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Meir Bialer, Boris Yagen, Ilan Winkler, Marshall Devor
  • Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid
    Patent number: 7232929
    Abstract: The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.
    Type: Grant
    Filed: February 15, 2004
    Date of Patent: June 19, 2007
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Meir Bialer, Boris Yagen, Eyal Sobol, Dan Kaufmann
  • Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives for treating psychiatric disorders
    Publication number: 20070043122
    Abstract: The invention relates to the use of 2,2,3,3 tetramethylcyclopropane carboxylic acid derivative compounds for the preparation of a medicament for treating a psychiatric disorder preferably a bipolar disorder. The invention additionally relates to the use of the compounds for the preparation of an inhibitor of MIP synthase and to a pharmaceutical composition comprising the compounds for treating a psychiatric disorder. A method for treating a psychiatric disorder preferably a bipolar disorder and a method for inhibiting an enzyme having MIP synthase activity is provided.
    Type: Application
    Filed: May 27, 2004
    Publication date: February 22, 2007
    Applicants: YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM, BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Meir Bialer, Boris Yagen, Haim Belmaker, Galila Agam, Galit Shaltiel