Patents by Inventor Meir Rigbi

Meir Rigbi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of recombinant factor Xa inhibitor of leech Hirudo medicinalis
    Patent number: 5801017
    Abstract: The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr.sup.26 -gly.sup.110 where tyr.sup.26 -gly.sup.110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn.sup.72 may be substituted by pro.The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: September 1, 1998
    Assignee: Bio-Technology General Corp.
    Inventors: Moshe M. Werber, Elisha P. Zeelon, Avigdor Levanon, Rachel Guy, Arie Goldlust, Meir Rigbi, Amos Panet, Meir Fischer
  • Factor Xa inhibitor and pharmaceutical compositions containing same
    Patent number: 5403596
    Abstract: A novel anticoagulant/modulator factor isolated from the saliva of the meinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: April 4, 1995
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, American National Red Cross
    Inventors: Meir Rigbi, Craig M. Jackson
  • Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
    Patent number: 5246715
    Abstract: A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of the Hirudinidae family. The composition contains various components, all having molecular weights lower than 2,000 daltons. The composition has an inhibitory activity against platelet aggregation induced by various aggregating agents, including Platelet Activating Factor-acether (PAF-acether), arachidonic acid, thrombin, ADP and epinephrine.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: September 21, 1993
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Miriam Orevi, Meir Rigbi, Amiram Eldor
  • Factor Xa inibitor from leech and pharmaceutical compositions containing same
    Patent number: 5182113
    Abstract: A novel anticoagulant/modulator factor isolated from the saliva of the medicinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: January 26, 1993
    Assignee: Bio-Technology General Corp.
    Inventors: Meir Rigbi, Craig M. Jackson
  • Collagen-specific enzyme with platelet aggregation inhibition properties
    Patent number: 5139944
    Abstract: The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50 k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: August 18, 1992
    Assignees: Biophram (UK) Limited, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Roy T. Sawyer, Meir Rigbi, Haim Levy, Fuad Iraqi
  • Derivatives of para-guanidino-L-phenylalanine and methods of preparing them
    Patent number: 4118575
    Abstract: The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine.The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.
    Type: Grant
    Filed: September 5, 1975
    Date of Patent: October 3, 1978
    Assignee: Choay S.A.
    Inventors: Meir Rigbi, Yakir Klausner, Pierre Lefrancier, Edgar Sache