Patents by Inventor Meixia ZHANG

Meixia ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11919976
    Abstract: The present invention relates to a preparation and purification method for cationic quaternary ammonium salt of sodium hyaluronate in homogeneous medium. By adding a homogeneous solvent and a sodium hyaluronate solid to a vessel, heating the vessel until the contents are dissolved to form a homogeneous system, adding an aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (GTA) to the homogeneous system, then adding a base catalyst, and stirring at a preset temperature to carry out a graft reaction, a graft product is obtained wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate. By using the method, a graft product wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate is obtained. Addition of salts is avoided during the reaction, a grafting yield up to 0.69 is obtained, and coagulation occurred to the product is effectively solved.
    Type: Grant
    Filed: April 11, 2023
    Date of Patent: March 5, 2024
    Assignee: SHANDONG FOCUSFREDA BIOTECH CO., LTD
    Inventors: Jinmao You, Lei Liu, Chuanli Kang, Shuiqiang Yu, Deqiang Zheng, Qing Li, Shuai Du, Xinxin Shi, Qiang Liu, Liwei Tang, Shaojie Lian, Meixia Zhang
  • Publication number: 20230342688
    Abstract: The present disclosure relates to a charging guidance method for fast charging loads based on an adjustable and graded charging service fee, including: establishing a fast charging load prediction model based on a trip chain and a Monte Carlo method to predict a fast charging demand and a spatial-temporal trajectory change of a user trip; deciding a charging location based on a weighted user charging location decision model, and calculating a fast charging load of each charging station; constructing a regional graded charging service fee adjustment model with a minimum sum of absolute values of voltage deviations of nodes in the distribution network in a region as an optimization objective, and optimizing and adjusting the charging service fee; and determining an optimal user charging location under fast charging loads by using the weighted user charging location decision model based on the adjusted charging service fee.
    Type: Application
    Filed: February 2, 2023
    Publication date: October 26, 2023
    Inventors: Meixia ZHANG, Licheng XU, Qianqian ZHANG, Xiu YANG
  • Publication number: 20230295351
    Abstract: The present invention relates to a preparation method for acetylated sodium hyaluronate, which pertains to the field of organic chemical synthesis, characterized in that, the preparation method includes the following steps: in the protective atmosphere of inert gas, subjecting a hyaluronate and an acetic anhydride to a catalytic reaction in an organic solvent with a catalyst added, adding a water absorbent during the reaction, obtaining a reaction liquid, subjecting a reaction liquid to post treatment, separation, purification, and drying to obtain a product. A too high or too low degree of substitution is effectively avoided in the present invention, so as to obtain a product with a degree of substitution of acetyl groups ranging from 2.7 to 3.2, with mild reactive materials and reacting conditions, and simple separation and purification steps.
    Type: Application
    Filed: February 28, 2022
    Publication date: September 21, 2023
    Applicant: SHANDONG FOCUSFREDA BIOTECH CO., LTD
    Inventors: Lei LIU, Chunxi WANG, Qing LI, Chuanli KANG, Jingjing SUN, Liwei TANG, Qiang LIU, Shaojie LIAN, Meixia ZHANG, Mengyi ZHANG, Ququan LI, Shuai DU