Patents by Inventor Mel C. Schroeder
Mel C. Schroeder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100298256Abstract: Lipid-modified phosphodiester nucleoside prodrugs are described herein. The prodrugs can be used to treat viral infections and cancer.Type: ApplicationFiled: December 23, 2008Publication date: November 25, 2010Inventors: Steven Dong, Mel C. Schroeder
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Patent number: 5714127Abstract: A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.Type: GrantFiled: June 7, 1995Date of Patent: February 3, 1998Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, John S. Kiely, Michael R. Pavia, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5702672Abstract: An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: October 10, 1995Date of Patent: December 30, 1997Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, Michael Kell, Michael R. Pavia, John S. Kiely, Mel C. Schroeder, Charles J. Stankovic, Steven Ware
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Patent number: 5633264Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.Type: GrantFiled: May 19, 1995Date of Patent: May 27, 1997Assignee: Warner-Lambert CompanyInventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
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Patent number: 5612002Abstract: A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.Type: GrantFiled: April 28, 1995Date of Patent: March 18, 1997Assignee: Warner-Lambert CompanyInventors: Donna R. Cody, Sheila H. H. DeWitt, John C. Hodges, John S. Kiely, Walter H. Moos, Michael R. Pavia, Bruce D. Roth, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5593642Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which my have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: June 5, 1995Date of Patent: January 14, 1997Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, John S. Kiely, Michael R. Pavia, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5582801Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: June 5, 1995Date of Patent: December 10, 1996Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, John S. Kiely, Michael R. Pavia, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5567391Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: June 5, 1995Date of Patent: October 22, 1996Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, John S. Kiely, Michael R. Pavia, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5565173Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction cubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable place with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: June 5, 1995Date of Patent: October 15, 1996Assignee: Warner-Lambert CompanyInventors: Sheila H. H. DeWitt, John S. Kiely, Michael R. Pavia, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5563155Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.Type: GrantFiled: May 3, 1995Date of Patent: October 8, 1996Assignee: Warner-Lambert CompanyInventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
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Patent number: 5461165Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.Type: GrantFiled: March 30, 1994Date of Patent: October 24, 1995Assignee: Warner-Lambert CompanyInventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
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Patent number: 5344940Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.Type: GrantFiled: June 28, 1993Date of Patent: September 6, 1994Assignee: Warner-Lambert CompanyInventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
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Patent number: 5324483Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.Type: GrantFiled: February 2, 1993Date of Patent: June 28, 1994Assignee: Warner-Lambert CompanyInventors: Donna R. Cody, Sheila H. H. DeWitt, John C. Hodges, John S. Kiely, Walter H. Moos, Michael R. Pavia, Bruce D. Roth, Mel C. Schroeder, Charles J. Stankovic
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Patent number: 5258528Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.Type: GrantFiled: October 26, 1992Date of Patent: November 2, 1993Assignee: Warner-Lambert CompanyInventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
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Patent number: 4945160Abstract: Novel processes for the coupling of alkyl, alkenyl, alkynyl, or aryl groups to the seven position of quinolines and naphthyridines is disclosed. Novel intermediates and final compounds having antibacterial activity are also described as well as the formulations for the same use.Type: GrantFiled: November 22, 1988Date of Patent: July 31, 1990Assignee: Warner-Lambert CompanyInventors: John S. Kiely, Lawrence E. Lesheski, Mel C. Schroeder
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Patent number: 4578473Abstract: An improved process for the preparation of 7-substituted amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids is described where an alkyl ester of a 6,7,8-trifluoro precursor is converted to a trialkylsilyl ester which fluorine at C.sub.7 is directly displaced to the desired product.Type: GrantFiled: April 15, 1985Date of Patent: March 25, 1986Assignee: Warner-Lambert CompanyInventors: John M. Domagala, Mel C. Schroeder