Patent number: 5622966
Abstract: A compound of the formula ##STR1## wherein * denotes an asymmetric carbon; X is C--H, C--F, C--Cl, C--OCH.sub.3, C--CF.sub.3, or N;R.sup.1 is a C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, or phenyl substituted by one or more halogen atoms;R.sup.2 is hydrogen, alkyl of 1 to 4 carbon atoms, or a cation;R.sup.3 is hydrogen, amino, or methyl;V, W, Y, and Z are each independently C--H, oxygen, nitrogen, or sulfur;R.sup.4 is hydrogen or one, two or three substituents independently selected from C.sub.1 -C.sub.4 -alkyl, halo-substituted C.sub.1 -C.sub.4 -alkyl, hydroxy-substituted C.sub.1 -C.sub.4 -alkyl, halogen, hydroxy, C.sub.1 -C.sub.4 -alkoxy, mercapto, amino, mono-(C.sub.1 -C.sub.4 -alkyl)amino, di-(C.sub.1 -C.sub.4 -alkyl)amino, formamido, mono-(C.sub.1 -C.sub.4 -alkyl)amido, di-(C.sub.1 -C.sub.4 -alkyl)amido, cyano, nitro, C.sub.1 -C.sub.4 -alkoxycarbonyl, carboxyl, aminomethyl, mono-(C.sub.1 -C.sub.4 -alkyl)aminomethyl, di-(C.sub.1 -C.sub.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
April 22, 1997
Assignee:
Warner-Lambert Company
Inventors:
Edgardo Laborde, Mel Schroeder