Patents by Inventor Melamed Dobroslav

Melamed Dobroslav has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and pharmacological composition for the diagnosis and treatment of male sub-fertility
    Patent number: 9149513
    Abstract: Methods for treating male sub-fertility by administering a pharmaceutical composition to a subject in need thereof are provided. The pharmaceutical compositions include an agent that causes a reduction in an effect of extracellular DNA on sperm cells. The agent may be, for example, an enzyme that degrades DNA such as DNase, a substance that blocks the interaction between cell free DNA and sperm cell surface receptors, a substance that binds to DNA, a substance that inhibits endogenous sperm cell DNase, a substance that inhibits a member of a signal transduction pathway mediated by DNA binding to sperm cell surface receptors, or an agent that stimulates production of an endogenous substance that causes a reduction in an antifertility effect of cell free DNA on sperm cells.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 6, 2015
    Assignee: PERINESS LTD.
    Inventors: Benjamin Bartoov, Ronen Yehuda, Melamed Dobroslav
  • METHOD AND PHARMACOLOGICAL COMPOSITION FOR THE DIAGNOSIS AND TREATMENT OF MALE SUB-FERTILITY
    Publication number: 20130121985
    Abstract: Methods for treating male sub-fertility by administering a pharmaceutical composition to a subject in need thereof are provided. The pharmaceutical compositions include an agent that causes a reduction in an effect of extracellular DNA on sperm cells. The agent may be, for example, an enzyme that degrades DNA such as DNase, a substance that blocks the interaction between cell free DNA and sperm cell surface receptors, a substance that binds to DNA, a substance that inhibits endogenous sperm cell DNase, a substance that inhibits a member of a signal transduction pathway mediated by DNA binding to sperm cell surface receptors, or an agent that stimulates production of an endogenous substance that causes a reduction in an antifertility effect of cell free DNA on sperm cells.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 16, 2013
    Inventors: Benjamin BARTOOV, Ronen YEHUDA, Melamed DOBROSLAV
  • Method and pharmacological composition for the diagnosis and treatment of male
    Publication number: 20110033438
    Abstract: Pharmaceutical compositions for treating male sub-fertility that include an agent that causes a reduction in an effect of extracellular DNA on sperm cells, are provided. The agent may be, for example, an enzyme that degrades DNA such as DNase, a substance that blocks the interaction between cell free DNA and sperm cell surface receptors, a substance that binds to DNA, a substance that inhibits endogenous sperm cell DNase, a substance that inhibits a member of a signal transduction pathway mediated by DNA binding to sperm cell surface receptors, or an agent that stimulates production of an endogenous substance that causes a reduction in an antifertility effect of cell free DNA on sperm cells. Also provided are methods for treating male sub-fertility by administering the pharmaceutical composition to a subject in need thereof.
    Type: Application
    Filed: October 18, 2007
    Publication date: February 10, 2011
    Applicant: PERINESS LTD.
    Inventors: Benjamin Bartoov, Ronen Yehuda, Melamed Dobroslav