Patents by Inventor Melanie A. Preston

Melanie A. Preston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poly(UG) polymerase, constructs, and methods of making and using the same
    Patent number: 10301605
    Abstract: Methods, kits, and compositions of matter relating to poly(UG) polymerases are disclosed. In one embodiment, a method includes: contacting an RNA substrate with a poly(UG) polymerase; and allowing the poly(UG) polymerase to add a poly(UG) sequence to the end of the RNA substrate by retaining contact between the RNA substrate and the poly(UG) polymerase for a period of time from about 1 second to about 28 days. The poly(UG) polymerase can be Caenorhabditis elegans RDE-3.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 28, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marvin P. Wickens, Melanie A. Preston
  • RNA tagging
    Patent number: 10160968
    Abstract: Methods, kits, and compositions of matter suitable for use in RNA Tagging are disclosed. In one embodiment, a method includes: expressing a fusion protein within the cellular environment, the fusion protein including at least part of the protein of interest and a tagging domain, the tagging domain introducing a selective tag to an RNA to which the fusion protein selectively binds, the selective tag including a selective tag sequence or a selective covalent modification; allowing the tagging domain to tag the RNA to which the protein of interest selectively binds by waiting for about 1 minute to about 28 days; and identifying the tagged RNA.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marvin P. Wickens, Christopher P. Lapointe, Melanie A. Preston
  • Poly(UG) Polymerase, Constructs, and Methods of Making and Using the Same
    Publication number: 20160145666
    Abstract: Methods, kits, and compositions of matter relating to poly(UG) polymerases are disclosed. In one embodiment, a method includes: contacting an RNA substrate with a poly(UG) polymerase; and allowing the poly(UG) polymerase to add a poly(UG) sequence to the end of the RNA substrate by retaining contact between the RNA substrate and the poly(UG) polymerase for a period of time from about 1 second to about 28 days. The poly(UG) polymerase can be Caenorhabditis elegans RDE-3.
    Type: Application
    Filed: November 17, 2015
    Publication date: May 26, 2016
    Inventors: Marvin P. Wickens, Melanie A. Preston
  • RNA Tagging
    Publication number: 20160138012
    Abstract: Methods, kits, and compositions of matter suitable for use in RNA Tagging are disclosed. In one embodiment, a method includes: expressing a fusion protein within the cellular environment, the fusion protein including at least part of the protein of interest and a tagging domain, the tagging domain introducing a selective tag to an RNA to which the fusion protein selectively binds, the selective tag including a selective tag sequence or a selective covalent modification; allowing the tagging domain to tag the RNA to which the protein of interest selectively binds by waiting for about 1 minute to about 28 days; and identifying the tagged RNA.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 19, 2016
    Inventors: Marvin P. Wickens, Christopher P. Lapointe, Melanie A. Preston