Abstract: An adhesive composition includes one or more polymerizable cyanoacrylate monomers, a polymerization initiator and a polymerization accelerator for the one or more polymerizable cyanoacrylate monomers. A system for treating living tissue includes a first reservoir containing one or more polymerizable cyanoacrylate monomers, a second reservoir in a non-contacting relationship with the first reservoir containing a polymerization initiator and accelerator for the one or more polymerizable cyanoacrylate monomers, and an applicator capable of combining the polymerizable cyanoacrylate monomer and the polymerization initiator and accelerator to form an adhesive composition and then applying the adhesive composition to living tissue. The initiator may be a quaternary ammonium salt, and the accelerator may be a trihydroxy tertiary amine.

Abstract: The present invention is directed to curable cyanoacrylate-based formulation containing a multi-functional amine initiator. A dual function amine, particularly Quadrol, provides a highly desirable balance of maximum cure temperature and setting time of cure with the same higher viscosity, non-running cyanoacrylate formulation. The present invention is also directed to systems that utilize the inventive formulations and methods for use of such formulations.

Abstract: An adhesive composition includes one or more polymerizable cyanoacrylate monomers, a polymerization initiator and a polymerization accelerator for the one or more polymerizable cyanoacrylate monomers. A system for treating living tissue includes a first reservoir containing one or more polymerizable cyanoacrylate monomers, a second reservoir in a non-contacting relationship with the first reservoir containing a polymerization initiator and accelerator for the one or more polymerizable cyanoacrylate monomers, and an applicator capable of combining the polymerizable cyanoacrylate monomer and the polymerization initiator and accelerator to form an adhesive composition and then applying the adhesive composition to living tissue. The initiator may be a quaternary ammonium salt, and the accelerator may be a trihydroxy tertiary amine.

Abstract: Adhesive compositions, particularly medical adhesive compositions, often include several components that may react differently to different sterilization processes, particularly when combined with one another. The present invention is directed to methods of sterilizing different components or groups of components of a final adhesive composition. The different components or groups of components may be sterilized in separate containers before packaging the components or groups of components within a kit, and thereafter sterilizing the kit.

Abstract: An adhesive composition is provided including one or more polymerizable cyanoacrylate monomers and boron trifluoride as a stabilizer or complexing agent. The adhesive composition may also include or be used with a decomplexing agent, particularly one or more quaternary ammonium fluoride salts or one or more quaternary ammonium ether salts. A polymerization initiator or accelerator may also be used. The viscosity of the adhesive composition may be controlled by addition of a thickening agent which may be a polymer or copolymer catalyzed by a boron trifluoride complex or compound. Methods for the application of the adhesive compositions to living tissue are also provided.

Abstract: Adhesive compositions, particularly medical adhesive compositions, often include several components that may react differently to different sterilization processes, particularly when combined with one another. The present invention is directed to methods of sterilizing different components or groups of components of a final adhesive composition. The different components or groups of components may be sterilized in separate containers before packaging the components or groups of components within a kit, and thereafter sterilizing the kit.

Abstract: Achieving lung volume reduction includes occluding a lumen of a bronchial tube of a lung to prevent air flow to at least a region of the lung. Bronchial occluders such as polymerizable materials and mechanical devices, such as sutures, staples, clips, clamps, foam, balloons, umbrellas and ball bearings are provided for occluding a bronchial tube. Methods include mixing thickeners or foaming agents with polymerizable compositions and introducing the mixture into a lumen of a bronchial tube. Mechanisms for mixing components and delivering the mixture to a lumen of a bronchial tube are also provided.