Patents by Inventor Melanie Adams

Melanie Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240360442
    Abstract: The invention involves the use of novel nucleic acid sequences to detect, modulate, ablate, inhibit or augment the transcription and therefore translation and expression of functionally-linked genes. The present disclosure is based on the novel finding that Transposable Element remnant (TEr) RNA or promoter non-processive transcripts (NPtx) have a high probability of aligning with high identity to transcriptional regulatory regions of functionally-linked genes, suggesting that they participate in beneficial transcriptional crosstalk.
    Type: Application
    Filed: April 25, 2023
    Publication date: October 31, 2024
    Applicant: Nuclear RNA Networks, Inc.
    Inventor: Melanie Adams
  • Patent number: 6025124
    Abstract: A TAR marker, method for detection and monitoring of HIV latency and activation and an assay for detection of the marker. The assay sensitively detects HIV transcription and monitors HIV transcriptional activity by detecting the presence of TAR fragments and full length transcripts, quantifying both and determining the ratio of short to long transcripts. A low ratio correlates with a latent-type transcriptional activity of HIV whereas the appearance of long transcripts signifies increased efficiency of transcriptional activity of HIV and the transition from latency to activation. The size difference between the TAR fragments appearing predominantly in latency and the full length transcripts appearing predominantly during the HIV activation is detected by RT-PCR assay that utilizes novel primers and probes. The obtained ratio is a sensitive tool in detection of HIV infection, the analysis of load of latent and active virus and monitoring the transition from the latent to active state of HIV replication.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: February 15, 2000
    Assignee: The Regents of the University of California
    Inventors: Melanie Adams, Joseph Romeo, Boris Matija Peterlin, Michael Paul Busch
  • Patent number: 5576176
    Abstract: A marker and method for detection and monitoring of HIV latency and activation and an assay for detection of the marker. The assay sensitively detects HIV transcription and monitors HIV transcriptional activity by detecting the presence of short and long transcripts, quantifying both and determining the ratio of short to long transcripts. Short transcripts are abundant and a low ratio correlates with a latent-type transcriptional activity of HIV whereas the appearance of long transcripts signifies increased efficiency of transcriptional activity of HIV and the transition from latency to activation. The size difference between the TAR fragments appearing predominantly in latency and the full length transcripts appearing predominantly during the HIV activation is detected by RT-PCR assay that utilizes novel primers and probes. The results are expressed as a ratio of short to long transcripts.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: November 19, 1996
    Assignee: The Regents of the University of California
    Inventors: Melanie Adams, Joseph Romeo, Boris M. Peterlin, Michael P. Busch