Patents by Inventor Melanie Arbour

Melanie Arbour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for the production of diphtheria toxin polypeptides
    Publication number: 20230331788
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 19, 2023
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • Systems and methods for the production of diphtheria toxin polypeptides
    Patent number: 11702456
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: July 18, 2023
    Assignee: National Research Council of Canada
    Inventors: Luke Masson, Melanie Arbour, Marie-Anne Gauriat
  • RECOMBINANT INTERFERON
    Publication number: 20220323546
    Abstract: Isolated, pure, soluble isoform free recombinant human interferon alpha 2b (rhIFN ?-2b). Methods of making the soluble isoform free rhIFN ?-2b. Stable compositions and formulations of isoform free rhIFN ?-2b are for administration generally for treatment and prevention of viral infections. In aspects, to prevent and/or minimize symptom(s) of viral infections such as respiratory infection(s) in a subject, in aspects SARS-COV2 infection.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 13, 2022
    Inventors: SCOTT RUDGE, LUKE MASSON, MÉLANIE ARBOUR, JULIE STRUBLE, JENAE LUELLEN
  • Systems and methods for the production of diphtheria toxin polypeptides
    Publication number: 20200231635
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 23, 2020
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • GENETICALLY ENGINEERED C1-UTILIZING MICROORGANISMS AND PROCESSES FOR THEIR PRODUCTION AND USE
    Publication number: 20180087024
    Abstract: Described are genetically engineered C1-utilizing bacteria for the preparation of dicarboxylic acids, e.g. succinic acid. For instance, the bacteria comprise a mutation in a gene encoding a tricarboxylic acid cycle (TCA) succinate dehydrogenase (Sdh), preferably a mutation which inactivates or reduces Sdh's activity. Processes for the production of the modified bacteria as well as their use in the preparation of succinic acid on a C1-compound as carbon source are also discussed.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 29, 2018
    Applicant: National Research Council of Canada
    Inventors: Martin G. Lamarche, Jonathan Perreault, Carlos Miguez, Melanie Arbour, Young Jun Choi