Patents by Inventor Melanie C. Betlach

Melanie C. Betlach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant narbonolide polyketide synthase
    Patent number: 6902913
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: June 7, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Recombinant narbonolide polyketide synthase
    Publication number: 20030162262
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Application
    Filed: May 29, 2002
    Publication date: August 28, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20030148469
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: July 22, 2002
    Publication date: August 7, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Recombinant narbonolide polyketide synthase
    Publication number: 20030104597
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Application
    Filed: February 22, 2001
    Publication date: June 5, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Recombinant narbonolide polyketide synthase
    Patent number: 6509455
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: January 21, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Polyketide synthase genes from Streptomyces venezuelae
    Patent number: 6503741
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 7, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Nucleic acids encoding narbonolide polyketide synthase enzymes from streptomyces narbonensis
    Patent number: 6303767
    Abstract: Host cells comprising recombinant vectors encoding the narbomycin polyketide synthase and narbomycin modification enzymes from Streptomyces narbonensis can be used to produce narbomycin, picromycin, methymycin, and neomethymycin. Recombinant DNA constructs comprising one or more narbomycin polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application in agriculture, medicine, and animal health.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: October 16, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Melanie C. Betlach, Robert McDaniel
  • Recombinant narbonolide polyketide synthase
    Patent number: 6117659
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: September 12, 2000
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang