Abstract: Embodiments of the disclosed technology provide reliable and fast communication of a human through a direct brain interface which detects the intent of the user. An embodiment of the disclosed technology comprises a system and method in which least one sequence of a plurality of stimuli is presented to an individual (using appropriate sensory modalities), and the time course of at least one measurable response to the sequence(s) is used to select at least one stimulus from the sequence(s). In an embodiment, the sequence(s) may be dynamically altered based on previously selected stimuli and/or on estimated probability distributions over the stimuli. In an embodiment, such dynamic alteration may be based on predictive models of appropriate sequence generation mechanisms, such as an adaptive or static sequence model.