Patents by Inventor Melanie G. Urbanchek
Melanie G. Urbanchek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220022906Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.Type: ApplicationFiled: October 5, 2021Publication date: January 27, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Nicholas B. LANGHALS, Cynthia Anne CHESTEK, Paul S. CEDERNA, Albert SHIH, Melanie G. URBANCHEK, Grant H. KRUGER, Jeffrey Stephen PLOTT, Jordan T. KREDA
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Patent number: 11185344Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.Type: GrantFiled: March 11, 2016Date of Patent: November 30, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Nicholas B. Langhals, Cynthia Anne Chestek, Paul S. Cederna, Albert Shih, Melanie G. Urbanchek, Grant H. Kruger, Jeffrey Stephen Plott, Jordan T. Kreda
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Patent number: 10779963Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.Type: GrantFiled: May 6, 2019Date of Patent: September 22, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Cynthia Anne Chestek, Melanie G. Urbanchek, Paul S. Cederna, Richard Brent Gillespie, Nicholas B. Langhals, Zachary Irwin, Daniel C. Ursu
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Publication number: 20190262145Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.Type: ApplicationFiled: May 6, 2019Publication date: August 29, 2019Inventors: Cynthia Anne CHESTEK, Melanie G. URBANCHEK, Paul S. CEDERNA, Richard Brent GILLESPIE, Nicholas B. LANGHALS, Zachary IRWIN, Daniel C. URSU
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Patent number: 10314725Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.Type: GrantFiled: November 13, 2015Date of Patent: June 11, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Cynthia Anne Chestek, Melanie G. Urbanchek, Paul S. Cederna, Richard Brent Gillespie, Nicholas B. Langhals, Zachary Irwin, Daniel C. Ursu
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Publication number: 20180042629Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.Type: ApplicationFiled: March 11, 2016Publication date: February 15, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Nicholas B. LANGHALS, Cynthia Anne CHESTEK, Paul S. CEDERNA, Albert SHIH, Melanie G. URBANCHEK, Grant H. KRUGER, Jeffrey Stephen PLOTT, Jordan T. KREDA
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Patent number: 9808616Abstract: The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.Type: GrantFiled: January 13, 2012Date of Patent: November 7, 2017Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSITY OF DELAWAREInventors: Paul S. Cederna, Melanie G. Urbanchek, David C. Martin
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Patent number: 9352146Abstract: The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and/or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.Type: GrantFiled: July 17, 2013Date of Patent: May 31, 2016Assignee: The Regents Of The University Of MichiganInventors: Nicholas B. Langhals, Paul S. Cederna, Melanie G. Urbanchek
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Publication number: 20160143751Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.Type: ApplicationFiled: November 13, 2015Publication date: May 26, 2016Inventors: Cynthia Anne CHESTEK, Melanie G. URBANCHEK, Paul S. CEDERNA, Richard Brent GILLESPIE, Nicholas B. LANGHALS, Zachary IRWIN, Daniel C. URSU
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Patent number: 9044347Abstract: A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a way to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).Type: GrantFiled: August 15, 2012Date of Patent: June 2, 2015Assignee: The Regents of The University of MichiganInventors: Paul S. Cederna, Brent M. Egeland, Mohammad Reza Abidian, Antonio Peramo, Melanie G. Urbanchek, Daryl R. Kipke, Sarah Richardson-Burns, David C. Martin, Eugene D. Daneshvar
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Publication number: 20140249645Abstract: A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).Type: ApplicationFiled: August 15, 2012Publication date: September 4, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: PAUL S. CEDERNA, BRENT M. EGELAND, MOHAMMAD REZA ABIDIAN, ANTONIO PERAMO, MELANIE G. URBANCHEK, DARYL R. KIPKE, SARAH RICHARDSON-BURNS, DAVID C. MARTIN, EUGENE D. DANESHVAR
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Publication number: 20140005763Abstract: The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.Type: ApplicationFiled: January 13, 2012Publication date: January 2, 2014Applicants: UNIVERSITY OF DELAWARE, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Paul S. Cederna, Melanie G. Urbanchek, David C. Martin
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Publication number: 20130304174Abstract: The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and/or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.Type: ApplicationFiled: July 17, 2013Publication date: November 14, 2013Inventors: Nicholas B. Langhals, Paul S. Cederna, Melanie G. Urbanchek