Patents by Inventor Melanie J. Loots

Melanie J. Loots has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414013
    Abstract: Compounds of the formula ##STR1## wherein Z is ##STR2## proline, pipecolic acid, an indolecarboxylic acid or an isoquinolinecarboxylic acid. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414017
    Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
    Patent number: 5223516
    Abstract: Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: June 29, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
    Patent number: 4849414
    Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: July 18, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Melanie J. Loots, Donald S. Karanewsky
  • 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
    Patent number: 4661592
    Abstract: This invention relates to a class of novel 4H-pyrimido[2,1-a]isoquinoline derivatives. The invention further relates to pharmaceutical compositions containing such 4H-pyrimido[2,1-a]isoquinoline-4-one derivatives and to the use of such compounds and compositions as anorectic agents. In particular, the novel 4H-pyrimido[2,1-a]isoquinoline-4-one derivatives are effective anorectic agents when administered orally.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: April 28, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Arthur L. Campbell, Suzanne Evans Radak, Melanie J. Loots
  • Bicycloheptane substituted ethers
    Patent number: 4647585
    Abstract: Bicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: March 3, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Melanie J. Loots, Steven E. Hall, Peter W. Sprague
  • Method of use of bicycloheptane substituted prostaglandin analogs as cardiovascular agents
    Patent number: 4542160
    Abstract: Bicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: September 17, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, Melanie J. Loots, Martin F. Haslanger
  • Substituted urido amino and imino acids and esters
    Patent number: H642
    Abstract: Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: June 6, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Floyd, Melanie J. Loots