Patents by Inventor Melanie R. A. Green

Melanie R. A. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of acalabrutinib
    Patent number: 10800787
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 13, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20200172514
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: February 6, 2020
    Publication date: June 4, 2020
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Acalabrutinib and Intermediates Thereof
    Publication number: 20200048264
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Application
    Filed: April 17, 2018
    Publication date: February 13, 2020
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the preparation of Veliparib and intermediates thereof
    Patent number: 10556887
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: February 11, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of lesinurad and intermediates thereof
    Patent number: 10351537
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: July 16, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Dasotraline and Intermediates Thereof
    Publication number: 20190194122
    Abstract: The present invention provides processes for the preparation of Dasotraline (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (2), or a salt thereof, and its deprotection to afford Dasotraline (1).
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Inventors: Prabhudas Bodhuri, Eduardo Gustavo Cammisa, Melanie R.A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of edoxaban and intermediates thereof
    Patent number: 10301322
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 28, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20190119257
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: October 23, 2018
    Publication date: April 25, 2019
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Lesinurad and Intermediates Thereof
    Publication number: 20180258057
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Edoxaban and Intermediates Thereof
    Publication number: 20180179226
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli