Abstract: A closed-loop, bioregenerative water purification system including a gravity-independent anaerobic membrane bioreactor capable of operating in the presence and absence of gravity, the bioreactor including an anaerobic bioreactor, a first membrane filtration unit, and a second membrane filtration unit, wherein the anaerobic bioreactor is configured to receive organic waste and hygiene water as inputs and break them down into constituent components using anaerobic microbes, wherein the first membrane filtration unit is configured to receive effluent output from the anaerobic bioreactor, return concentrate to the anaerobic bioreactor, and output permeate to the second membrane filtration unit, and wherein the second membrane filtration unit is configured to receive the permeate output from the first membrane filtration unit, separate biogas from the permeate, and output nutrient-rich water.