Patents by Inventor Melanie Von Brandenstein

Melanie Von Brandenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TUMOR AND METASTASIZING MARKER
    Publication number: 20250122581
    Abstract: The present invention relates to methods for detecting a malignant tumor in an individual by means of determining the Vimentin variant 3 (Vim3) level in the individual's blood serum S and/or the accumulation of Vim3 polypeptide in cell nuclei. Furthermore, the present invention refers to an antineoplastic agent for use in a method for treating an individual bearing a malignant tumor, wherein said antineoplastic agent is a Vim3 inhibitor and/or wherein the malignant tumor is endothelin B receptor negative.
    Type: Application
    Filed: December 17, 2024
    Publication date: April 17, 2025
    Applicant: UNIVERSITAET ZU KOELN
    Inventors: Melanie Von BRANDENSTEIN, Jochen FRIES, Tobias KOHL, Monika Stefanie SCHLOSSER, Andreas STOG
  • Method for determining the fertility of spermatozoa comprising detection of vimentin variant 3
    Patent number: 11774441
    Abstract: The present invention relates to a method for determining the fertility of spermatozoa, said method comprising determining the total content of Vimentin variant 3 (Vim3) per spermatozoon and/or the spatial localization of the Vim3 in the spermatozoa, wherein a decreased amount of total content and/or decreased amount of (or even missing) accumulation of Vim3 in the mid piece of the spermatozoa indicates decreased fertility. Further, the present invention refers to a dipstick usable for this method. Moreover, the present invention relates to further methods and uses in the context of the present invention.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: October 3, 2023
    Assignee: Universität zu Köln
    Inventors: Melanie von Brandenstein, Ali Tok
  • Method for diagnosis of a benign renal oncocytoma by means of VIM3
    Patent number: 11585815
    Abstract: The present invention relates to a method for the diagnosis of a benign oncocytoma and a method to differentiate a benign oncocytoma from malignant renal cell carcinoma, a kit for use in these methods, as well as antibody relating thereto, a hybridoma cell capable of producing the same as well as the uses relating thereto.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: February 21, 2023
    Assignee: UNIVERSITÄT ZU KOLN
    Inventors: Jochen Fries, Melanie Von Brandenstein
  • TEST FOR DETECTING MALIGNANT KIDNEY CANCER
    Publication number: 20210148914
    Abstract: The present invention relates to a method for detecting malignant kidney cancer in an individual, said method conducted in vitro comprising the steps of providing a body fluid sample, in particular a urine sample, obtained from the individual, and determining one or more biomarker levels selected from the group consisting of the Mxi-2 level, the Vim3 level, the MAPKp38 level and the Atg7 level in the sample. Further, the present invention refers to a kit and a dipstick for use in such method.
    Type: Application
    Filed: July 10, 2018
    Publication date: May 20, 2021
    Applicant: Universität zu Köln
    Inventors: Melanie von Brandenstein, Jochen Fries
  • TUMOR AND METASTASIZING MARKER
    Publication number: 20200232044
    Abstract: The present invention relates to methods for detecting a malignant tumor in an individual by means of determining the Vimentin variant 3 (Vim3) level in the individual's blood serum S and/or the accumulation of Vim3 polypeptide in cell nuclei. Furthermore, the present invention refers to an antineoplastic agent for use in a method for treating an individual bearing a malignant tumor, wherein said antineoplastic agent is a Vim3 inhibitor and/or wherein the malignant tumor is endothelin B receptor negative.
    Type: Application
    Filed: October 2, 2018
    Publication date: July 23, 2020
    Applicant: Universität zu Köln
    Inventors: Melanie von Brandenstein, Jochen Fries, Tobias Kohl, Monika Stefanie Schlosser, Andreas Stog
  • METHOD FOR DETERMINING THE FERTILITY OF SPERMATOZOA
    Publication number: 20200110076
    Abstract: The present invention relates to a method for determining the fertility of spermatozoa, said method comprising determining the total content of Vimentin variant 3 (Vim3) per spermatozoon and/or the spatial localization of the Vim3 in the spermatozoa, wherein a decreased amount of total content and/or decreased amount of (or even missing) accumulation of Vim3 in the mid piece of the spermatozoa indicates decreased fertility. Further, the present invention refers to a dipstick usable for this method. Moreover, the present invention relates to further methods and uses in the context of the present invention.
    Type: Application
    Filed: April 6, 2018
    Publication date: April 9, 2020
    Applicant: Universität zu Köln
    Inventors: Melanie von Brandenstein, Ali Tok
  • METHODS OF DIAGNOSING AND DIFFERENTIATING ONCOCYTOMA AND MALIGNANT RENAL CARCINOMA AS WELL AS PRODUCTS AND USES RELATING THERETO
    Publication number: 20160047814
    Abstract: The present invention relates to a method for the diagnosis of a benign oncocytoma and a method to differentiate a benign oncocytoma from malignant renal cell carcinoma, a kit for use in these methods, as well as antibody relating thereto, a hybridoma cell capable of producing the same as well as the uses relating thereto.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 18, 2016
    Inventors: Jochen Fries, Melanie Von Brandenstein