Abstract: Disclosed are compounds of Formula (1) and pharmaceutically acceptable salts thereof, wherein ?, ?, n, R4, R5, R6, R8, R9, R10, R11, X1, X2, X3 and X7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions comprising them, and to their use for treating diseases, disorders, and conditions associated with GPR139.

Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: A seat buckle that accommodates different types and styles of child seats. The standard platform can be used across a variety of baby to child seats. The belt has a button on the front, with a safety mechanism on the back that must be articulated to enable activation of the belt buckle. The buckle may take the configuration of an adapter allows a parent to install the safety buckle for a child seat. Adapter on a pre-existing seat. The belt ideally configured for a “Y” style buckle where straps extend over each shoulder and a single strap passes between the legs of the child. This allows the safety to pass or be blocked between the two belt buckle components of the shoulder straps. This also accommodates most of the buckles that are being produced.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: Improvements child or baby seat are disclosed. The improvements include a common design that accommodates different types and styles of child seats. The standard platform can be used across a variety of baby to child seats. The belt has a button on the front, with a safety mechanism on the back that must be articulated to enable activation of the belt buckle. The buckle may take4 the configuration of an adapter allows a parent to install the safety buckle for a child seat. Adapter on a pre-existing seat. The belt ideally configured for a “Y” style buckle where straps extend over each shoulder and a single strap passes between the legs of the child. This allows the safety to pass or be blocked between the two belt buckle components of the shoulder straps. This also accommodates most of the buckles that are being produced.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Abstract: The present invention provides a method of treating acute heart failure by administering a compound of the formula: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a method of treating acute heart failure by administering a compound of the formula: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD and pharmaceutical compositions thereof.

Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.