Patents by Inventor Melinda Faulkner

Melinda Faulkner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prokaryotic host cells for expressing proteins rich in disulfide bonds
    Patent number: 7816117
    Abstract: The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor molecule contained at least one disulfide bond. The methods employ a host cell modified to more efficiently produce properly folded disulfide bond containing proteins. The host cells generally contain a mutation in one or more reductase genes, and can be further genetically modified to increase their growth rate, and are further optionally modified to increase the expression of a catalyst of disulfide bond formation. Host cells, methods for u sing such to produce proteins of interest, proteins of interest produced by these methods are within the scope of the invention.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: October 19, 2010
    Assignees: President and Fellows Of Harvard College, The University of Texas System
    Inventors: Jonathan Beckwith, Daniel Ritz, Melinda Faulkner, Stephanie Gon, George Georgiou
  • Prokaryotic host cells for expressing proteins rich in disulfide bonds
    Publication number: 20070254334
    Abstract: The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor molecule contained at least one disulfide bond. The methods employ a host cell modified to more efficiently produce properly folded disulfide bond containing proteins. The host cells generally contain a mutation in one or more reductase genes, and can be further genetically modified to increase their growth rate, and are further optionally modified to increase the expression of a catalyst of disulfide bond formation. Host cells, methods for u sing such to produce proteins of interest, proteins of interest produced by these methods are within the scope of the invention.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 1, 2007
    Applicants: President and Fellows of Harvard College, The Board of Regents, The University of Texas System
    Inventors: Jonathan Beckwith, Daniel Ritz, Melinda Faulkner, Stephanie Gon, George Georgiou