Patents by Inventor Melinda G. Hollingshead

Melinda G. Hollingshead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating renal cancer using 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde
    Patent number: 8273797
    Abstract: The present invention features methods of treating a mammalian subject having renal cancer by administration of 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: September 25, 2012
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Susan D. Mertins, Susan E. Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
  • TREATING RENAL CANCER USING A 4-[BIS[2-[(METHYLSULFONYL)OXY]ETHYL]AMINO]-2-METHYL-BENZALDEHYDE
    Publication number: 20110269840
    Abstract: The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
    Type: Application
    Filed: July 5, 2011
    Publication date: November 3, 2011
    Inventors: Susan D. Mertins, Susan E. Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
  • Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde
    Patent number: 7989501
    Abstract: The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: August 2, 2011
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Susan D. Mertins, Susan Elaine Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
  • Treating or Preventing Renal Cancer Using a Dimethane Sulfonate
    Publication number: 20090131536
    Abstract: The present invention features methods of treating renal cancer by administration of certain dimethylsulfonate compounds. The present invention further features administration protocols and dosing schedules for methods of treating patients suffering from renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
    Type: Application
    Filed: October 14, 2005
    Publication date: May 21, 2009
    Applicant: GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Susan D. Mertins, Susan E. Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
  • Geldanamycin derivative and method of treating cancer using same
    Patent number: 6890917
    Abstract: A geldanamycin derivative exhibiting significant preliminary in vivo activity, particularly significant oral in vivo activity, and a method of treating or preventing cancer in a host comprising administering a geldanamycin derivative to a host in an amount sufficient to treat or prevent cancer.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: May 10, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenneth M. Snader, B. Rao Vishnuvajjala, Melinda G. Hollingshead, Edward A. Sausville
  • Geldanamycin derivative and method of treating cancer using same
    Publication number: 20040053909
    Abstract: A geldanamycin derivative exhibiting significant preliminary in vivo activity, particularly significant oral in vivo activity, and a method of treating or preventing cancer in a host comprising administrering a geldanamycin derivative to a host in an amount sufficient to treat or prevent cancer.
    Type: Application
    Filed: September 16, 2003
    Publication date: March 18, 2004
    Inventors: Kenneth M. Snader, B. Rao Vishnuvajjala, Melinda G. Hollingshead, Edward A. Sausville
  • Method of evaluating chemotherapeutic agents in vivo
    Patent number: 5698413
    Abstract: The present invention relates to a method of screening chemotherapeutic agents in vivo. The method comprises implanting into a laboratory animal a biocompatible, semi-permeable encapsulation device containing a target cell-line, treating the laboratory animal with a test agent, then evaluating the target cells for reaction to the test agent.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: December 16, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Melinda G. Hollingshead
  • Method of potentiating an immune response
    Patent number: 5075109
    Abstract: A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immuity. Related compositions are also provided.
    Type: Grant
    Filed: March 18, 1988
    Date of Patent: December 24, 1991
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Thomas R. Tice, Richard M. Gilley, John H. Eldridge, Jay K. Staas, Melinda G. Hollingshead, William M. Shannon