Patents by Inventor Melissa Blackman

Melissa Blackman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes
    Patent number: 10434197
    Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: October 8, 2019
    Assignees: University of Delaware, University of Southern California
    Inventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
  • Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes
    Publication number: 20130266512
    Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.
    Type: Application
    Filed: July 21, 2011
    Publication date: October 10, 2013
    Applicants: University of Southern California, University of Delaware
    Inventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
  • Tetrazine-based bio-orthogonal coupling reagents and methods
    Patent number: 8236949
    Abstract: Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: August 7, 2012
    Assignee: University of Delaware
    Inventors: Joseph Michael Fox, Melissa Blackman, Maksim Royzen, Ni Yan
  • TETRAZINE-BASED BIO-ORTHOGONAL COUPLING REAGENTS AND METHODS
    Publication number: 20090023916
    Abstract: Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.
    Type: Application
    Filed: July 17, 2008
    Publication date: January 22, 2009
    Applicant: University of Delaware
    Inventors: Joseph Michael Fox, Melissa Blackman, Maksim Royzen, Ni Yan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20070049536
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: October 3, 2006
    Publication date: March 1, 2007
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20070032434
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 8, 2007
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050288233
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 29, 2005
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan