Patents by Inventor Melissa D. Bosak

Melissa D. Bosak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids
    Patent number: 8658413
    Abstract: Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”], are also disclosed.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: February 25, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Melissa D. Bosak, Michael W. Bostick, Hongxian He, Seung-Pyo Hong, Dana M. Walters Pollak, Pamela L. Sharpe, Yehong Jamie Wang, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
  • MUTANT HPGG MOTIF AND HDASH MOTIF DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
    Publication number: 20120052549
    Abstract: Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”], are also disclosed.
    Type: Application
    Filed: August 26, 2011
    Publication date: March 1, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Melissa D. Bosak, Michael W. Bostick, Hongxian He, Seung-Pyo Hong, Dana M. Walters Pollak, Pamela L. Sharpe, Yehong Jamie Wang, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
  • Optimized bacterial host strains of 16a
    Patent number: 7232666
    Abstract: Methanotrophic bacterial strains are provided that have been optimized for the production of carotenoid compounds through the down-regulation of one or more of the crtN1, ald, crtN2 and crtN3 genes of the carotenoid biosynthetic pathway. The resulting strains lack pigmented C30 carotenoid compounds, and show an increase in the production of C40 carotenoids. The use of the optimized host strains for the production of the C40 carotenoids canthaxanthin and astaxanthin is also described.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: June 19, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Pamela L. Sharpe, Qiong Cheng, Melissa D. Bosak, Luan Tao, Natalia Sedkova