Patents by Inventor Melissa H. Brown

Melissa H. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of endotoxin-associated disorders with cationic peptides
    Patent number: 5789377
    Abstract: A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: August 4, 1998
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Kevin L. Piers, Melissa H. Brown, Niamh Kelly
  • CEMA cationic peptide and polynucleotides encoding cEMA
    Patent number: 5707855
    Abstract: Method for recombinant production of cationic peptides and a novel polycationic antibacterial peptide.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: January 13, 1998
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Kevin L. Piers, Melissa H. Brown
  • Treatment of endotoxin-associated disorders with cationic peptides
    Patent number: 5688767
    Abstract: A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
    Type: Grant
    Filed: March 13, 1996
    Date of Patent: November 18, 1997
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Kevin L. Piers, Melissa H. Brown, Niamh Kelly
  • Cationic peptides and method for production
    Patent number: 5593866
    Abstract: A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity is also provided.
    Type: Grant
    Filed: December 20, 1995
    Date of Patent: January 14, 1997
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Kevin L. Piers, Melissa H. Brown