Patents by Inventor Melissa J. Moore

Melissa J. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED MESSENGER RNA COMPRISING FUNCTIONAL RNA ELEMENTS
    Publication number: 20230257738
    Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.
    Type: Application
    Filed: September 20, 2022
    Publication date: August 17, 2023
    Inventors: Melissa J. MOORE, Caroline KÖHRER, Ruchi JAIN, Vladimir PRESNYAK
  • Modified messenger RNA comprising functional RNA elements
    Patent number: 11485972
    Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: November 1, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Melissa J. Moore, Caroline Köhrer, Ruchi Jain, Vladimir Presnyak
  • PREPARATION OF LIPID NANOPARTICLES AND METHODS OF ADMINISTRATION THEREOF
    Publication number: 20210378980
    Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.
    Type: Application
    Filed: September 20, 2019
    Publication date: December 9, 2021
    Inventors: Allen HORHOTA, Christopher Karl MCLAUGHLIN, Jessica CHENEY, Ben GELDHOF, Jeffrey HRKACH, Melissa J. MOORE, Stephen G. HOGE
  • MESSENGER RNA COMPRISING FUNCTIONAL RNA ELEMENTS
    Publication number: 20210163928
    Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, in particular C-rich or CG-rich elements, which provide a desired translational regulatory activity to the mRNA.
    Type: Application
    Filed: April 11, 2019
    Publication date: June 3, 2021
    Inventors: David REID, Caroline KÖHRER, Ruchi JAIN, Melissa J. MOORE, Scott DONOVAN, Aaron LARSEN, Vladimir PRESNYAK
  • METHODS OF PREPARING MODIFIED RNA
    Publication number: 20200362382
    Abstract: The present disclosure relates to methods for preparing a modified RNA comprising enzymatically ligating an acceptor moiety having a 3?-hydroxyl group to the 5?-end of a donor moiety (e.g., installation of 5?-triphosphate groups, mRNA caps, or cap-like structures on chemically synthesized RNA or installation of 5?-triphosphate groups, mRNA caps, cap-like structures, or non-cap like structures on enzymatically prepared RNA).
    Type: Application
    Filed: August 17, 2018
    Publication date: November 19, 2020
    Inventors: Kristen OTT, Aaron LARSEN, I-Ping CHAN, Jennifer NELSON, William ISSA, Melissa J. MOORE
  • MODIFIED MESSENGER RNA COMPRISING FUNCTIONAL RNA ELEMENTS
    Publication number: 20200208145
    Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.
    Type: Application
    Filed: May 18, 2018
    Publication date: July 2, 2020
    Applicant: ModernaTX, Inc.
    Inventors: Melissa J. MOORE, Caroline KÖHRER, Ruchi JAIN, Vladimir PRESNYAK
  • Compositions and methods for constructing cDNA libraries that allow for mapping the 5? and 3? ends of RNAs
    Patent number: 9828600
    Abstract: This disclosure provides methods and compositions for preparing and constructing cDNA libraries.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: November 28, 2017
    Assignee: University of Massachusetts
    Inventors: Melissa J. Moore, Erin E. Heyer, Emiliano P. Ricci, Hakan Ozadam, Can Cenik, Xin Li
  • Deducing Exon Connectivity by RNA-Templated DNA Ligation/Sequencing
    Publication number: 20150240232
    Abstract: A technology is described that is capable of generating high-throughput sequencing (HTS) read length DNA products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an HTS-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide.
    Type: Application
    Filed: January 22, 2015
    Publication date: August 27, 2015
    Inventors: Phillip D. Zamore, Melissa J. Moore, Christian Roy
  • Compositions and Methods for Constructing cDNA Libraries that Allow for Mapping the 5' and 3' Ends of RNAs
    Publication number: 20150099671
    Abstract: This disclosure provides methods and compositions for preparing and constructing cDNA libraries.
    Type: Application
    Filed: September 22, 2014
    Publication date: April 9, 2015
    Inventors: Melissa J. Moore, Erin E. Heyer, Emiliano P. Ricci, Hakan Ozadam, Can Cenik, Xin Li
  • Deducing exon connectivity by RNA-templated DNA ligation/sequencing
    Patent number: 8975019
    Abstract: A technology is described that is capable of generating high-throughput sequencing (HTS) read length DNA products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an HTS-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: March 10, 2015
    Assignee: University Of Massachusetts
    Inventors: Phillip D. Zamore, Melissa J. Moore, Christian Roy
  • Deducing Exon Connectivity by RNA-Templated DNA Ligation/Sequencing
    Publication number: 20110092375
    Abstract: A technology is described that is capable of generating high-throughput sequencing (HTS) read length DNA products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an HTS-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide.
    Type: Application
    Filed: October 18, 2010
    Publication date: April 21, 2011
    Inventors: Phillip D. Zamore, Melissa J. Moore, Christian Roy