Abstract: A system and method for alignment. In some embodiments, the method includes measuring a first offset, the first offset being an offset along a first direction between a first alignment mark and a second alignment mark, the first alignment mark being an alignment mark on a first edge of a source die, the second alignment mark being an alignment mark on a target wafer, and the first direction being substantially parallel to the first edge of the source die.

Abstract: The present disclosure relates to improved processes for preparing 4-amino-6-(heterocyclic)picolinates.

Abstract: A method of forming a compound of formula (I) is provided. Some embodiments of the compound of formula (I) are known to have herbicidal activity. The method comprises combining a compound of formula (II) and a compound of formula (IIIa) or (IIIb), or a salt or ester thereof: in a liquid mixture comprising the compounds of formula (II), formula (IIIa) or (IIIb), water, a non-aqueous solvent, a surfactant, a catalyst, and a ligand at certain temperature, pH, and HLB ranges to form a chemical reaction product mixture comprising the compound of formula (I) and by-products.

Abstract: The disclosure provides compositions, methods, and devices for use in delivering Mitomycin-C(MMC), an antineoplastic chemotherapy drug often used for bladder instillations to treat bladder cancer, which degrades in both acidic and alkaline environments. The disclosure provides a solution of buffered MMC (or a different drug) in 50% propylene glycol that maintains a pH from 7.0 to 8.0 when introduced into acidic solutions (pH of 5.0) and is stable when stored at 2-8° C. for greater than 134 days. This formulation can be produced in an FDA registered 503B Outsourcing facility in a pre-filled, ready-to-administer syringe kit with pre-attached closed system transfer device and accessories required for bladder instillation.

Abstract: Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.

Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.

Abstract: A method, computer-readable medium, and apparatus for classifying IP network traffic are disclosed. For example, a method may include a processor for applying a regularized probabilistic model to internet protocol network traffic for performing geolocation, wherein the internet protocol network traffic contains internet protocol address information, detecting an outlier in the internet protocol network traffic, wherein the outlier is associated with a transaction over a network, and performing a remedial action to address the outlier.

Abstract: A method for detecting anomalous streaming network traffic data in real time includes: creating an anomaly detection model including a singular value matrix and a data pattern matrix from a matrix of historical network traffic data; storing the singular value matrix and the data pattern matrix of the anomaly detection model; receiving streaming network traffic data; performing a log transform on the streaming network traffic data; applying the anomaly detection model to a matrix of the streaming network traffic data in real time as the streaming network traffic data is received; detecting anomalous patterns in the streaming network traffic data based on patterns identified by the anomaly detection model; and associating the anomalous patterns in the streaming network traffic data with IP addresses.

Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.

Abstract: A method for detecting anomalous streaming network traffic data in real time includes: creating an anomaly detection model including a singular value matrix and a data pattern matrix from a matrix of historical network traffic data; storing the singular value matrix and the data pattern matrix of the anomaly detection model; receiving streaming network traffic data; performing a log transform on the streaming network traffic data; applying the anomaly detection model to a matrix of the streaming network traffic data in real time as the streaming network traffic data is received; detecting anomalous patterns in the streaming network traffic data based on patterns identified by the anomaly detection model; and associating the anomalous patterns in the streaming network traffic data with IP addresses.

Abstract: A processing system including at least one processor may obtain network traffic data of a network, including a first set of flow data associated with a first node, determine an anomaly factor of the first node from the network traffic data quantifying a deviation of the first set of flow data from a normal flow data associated with the first node, generate an exposure score of the first node in accordance with a measured influence of the first node in the network and the anomaly factor, generate a persistence score of the first node in accordance with a reputation measure of the first node and a measure of a recurrence of anomalous flow data associated with the first node, calculate a threat level of the first node from the exposure score and the persistence score, and reconfigure at least one aspect of the network in response to the threat level.

Abstract: A processing system including at least one processor may obtain network traffic data of a network, including a first set of flow data associated with a first node, determine an anomaly factor of the first node from the network traffic data quantifying a deviation of the first set of flow data from a normal flow data associated with the first node, generate an exposure score of the first node in accordance with a measured influence of the first node in the network and the anomaly factor, generate a persistence score of the first node in accordance with a reputation measure of the first node and a measure of a recurrence of anomalous flow data associated with the first node, calculate a threat level of the first node from the exposure score and the persistence score, and reconfigure at least one aspect of the network in response to the threat level.

Abstract: A method, computer-readable medium, and apparatus for classifying IP network traffic are disclosed. For example, a method may include a processor for applying a regularized probabilistic model to internet protocol network traffic for performing geolocation, wherein the internet protocol network traffic contains internet protocol address information, detecting an outlier in the internet protocol network traffic, wherein the outlier is associated with a transaction over a network, and performing a remedial action to address the outlier.

Abstract: An article of manufacture, namely a poultry cut food product, and a method of producing the article of manufacture. The article of manufacture includes a portion cut of the thigh of a poultry item or other bird.

Abstract: A method for detecting anomalous streaming network traffic data in real time includes: creating an anomaly detection model including a singular value matrix and a data pattern matrix from a matrix of historical network traffic data; storing the singular value matrix and the data pattern matrix of the anomaly detection model; receiving streaming network traffic data; performing a log transform on the streaming network traffic data; applying the anomaly detection model to a matrix of the streaming network traffic data in real time as the streaming network traffic data is received; detecting anomalous patterns in the streaming network traffic data based on patterns identified by the anomaly detection model; and associating the anomalous patterns in the streaming network traffic data with IP addresses.

Abstract: A specimen testing system has holders that hold a specimen for testing. The holders brace the specimen so that a load may be applied. A load applicator applies a load to the specimen at a location that is between the holders bracing the specimen. A user may adjust the load applicator until it applies the desired load to the specimen. If desired, a user may apply rotation to a specimen while it is experiencing a load by using a specimen rotation system. The user may continue to adjust the load applied to the specimen or continue to rotate the specimen during loading until the specimen fails.

Abstract: A device to be worn on a user's head is provided for promoting back sleeping. The device includes first and second stabilizers that have a head engaging surface and a bulge portion that extends outwardly from the head engaging surface, such as in the shape of a triangular prism. The first and second stabilizers are supported by a connecting member, such as a band that is worn around the user's head. When in use, the user is able to lie on his or her back on a sleep surface, such that the first and second stabilizers are positioned on opposite sides of the user's head. In this way, lateral movement of the user's head is limited to encourage back sleeping and avoid or minimize the pressure that may otherwise be applied to certain areas of the face, such that the occurrence of sleep wrinkles can be reduced.

Abstract: Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Abstract: The invention relates to compounds having formula (I): Scaffold-[L-(Antigen)t]y (I) wherein Antigen represents at least a portion of a target antigen for modulating an immune response; wherein t is 0 or an integer of at least 1; wherein y is at least 1; wherein the number of Antigens on the Scaffold is at least 2; wherein L is a linking group or a covalent bond, wherein when L is a covalent bond, the covalent bond is a single bond attached to a sp or sp2 hybridized atom of the Scaffold and when L is a linking group, the linking group is attached to the Scaffold through a single bond attached to a sp or sp2 hybridized atom; whereby the Scaffold is sufficiently rigid to maintain the relative position of the single bonds attached to sp or sp2 hybridized atoms. Further described are compositions containing the compounds and methods of using them.