Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The following is directed to an abrasive particle having a body including a core and a coating overlying at least a portion of the core. The coating can include a content of lithium. In an embodiment, the coating can further include silicon, oxygen, or a combination thereof.

Abstract: A proton beam imaging system includes: a proton beam generator to generate a proton beam; a proton beam modulator through which the proton beam passes positioned between the proton beam generator and an image target; and a proton beam detector positioned to detect the proton beam existing the image target; wherein the proton beam modulator comprises: a rotating wheel having an axis of rotation positioned so that the proton beam passes through the axis of rotation and the axis of rotation is perpendicular to the proton beam; a first modulating portion comprising a first material portion and a second material portion through which a proton beam passes; and a second modulating portion comprising a third material portion and a fourth material portion through with the proton beam passes; wherein the first and second wedges are positioned opposite each other on the rotating wheel.

Abstract: A proton beam imaging system includes: a proton beam generator to generate a proton beam; a proton beam modulator through which the proton beam passes positioned between the proton beam generator and an image target; and a proton beam detector positioned to detect the proton beam existing the image target; wherein the proton beam modulator comprises: a rotating wheel having an axis of rotation positioned so that the proton beam passes through the axis of rotation and the axis of rotation is perpendicular to the proton beam; a first modulating portion comprising a first material portion and a second material portion through which a proton beam passes; and a second modulating portion comprising a third material portion and a fourth material portion through with the proton beam passes; wherein the first and second wedges are positioned opposite each other on the rotating wheel.

Abstract: Described herein in several embodiments are a system, method and apparatus for measuring platelet thrombus volume of a blood sample. In some embodiments, the present invention comprises a microfluidic apparatus having a blood input that receives the blood sample and a plurality of flow channels. In some embodiments of the present invention, each flow channel has a non-stenotic region that receives a portion of the blood sample from the blood input and a stenotic region for creating a discrete initial shear rate in the flow channel. The initial shear rate in the flow channel can be from approximately 500 s?1 to approximately 13000 s?1. The stenotic region, or a narrowing or stricture of the flow channel passageway, is used to simulate a partial blockage of a blood vessel that can result in thrombosis within the blood vessel.

Abstract: A reconfigurable optical add-drop multiplexer is disclosed including an optical splitter receiving an input optical signal and splitting the input optical signal into a dropped optical signal and an express optical signal; a wavelength blocker optically coupled to the optical splitter, the wavelength blocker blocking particular wavelengths in the express optical signal; a cassette having a plurality of slots capable of accepting a plurality of pluggable optical filters; at least one pluggable optical filter optically coupled to the optical splitter, the pluggable optical filter filtering wavelengths so as to output a particular wavelength channel from the dropped optical signal; and an optical combiner optically coupled to the wavelength blocker and to an optical add path on which an optical add signal may be carried, the optical combiner combining the express optical signal having particular wavelengths expressed by the wavelength blocker and the optical add signal.