Patents by Inventor Melissa S. Pattee

Melissa S. Pattee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rolling circle amplification detection of RNA and DNA
    Patent number: 6783943
    Abstract: Rolling circle amplification (RCA) has been useful for detecting point mutations in isolated nucleic acids, but its application in cytological preparations has been problematic. By pretreating cells with a combination of restriction enzymes and exonucleases, we demonstrate RCA in solution and in situ to detect gene copy number and single base mutations. It can also detect and quantify transcribed RNA in individual cells, making it a versatile tool for cell-based assays.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: August 31, 2004
    Assignee: The Regents of the University of California
    Inventors: Allen T. Christian, Melissa S. Pattee, Cristina M. Attix, James D. Tucker
  • Rolling circle amplification detection of RNA and DNA
    Publication number: 20020177142
    Abstract: Rolling circle amplification (RCA) has been useful for detecting point mutations in isolated nucleic acids, but its application in cytological preparations has been problematic. By pretreating cells with a combination of restriction enzymes and exonucleases, we demonstrate RCA in solution and in situ to detect gene copy number and single base mutations. It can also detect and quantify transcribed RNA in individual cells, making it a versatile tool for cell-based assays.
    Type: Application
    Filed: December 18, 2001
    Publication date: November 28, 2002
    Applicant: The Regents of the University of California
    Inventors: Allen T. Christian, Melissa S. Pattee, Cristina M. Attix, James D. Tucker