Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: Methods are disclosed that include receiving electronic content data associated with an electronic content provider comprising: a content campaign identification associated with a virtual token, and provider-identified platform identifications that identify platforms on which the content campaign may be initiated; receiving input from the user comprising: a user identification, a virtual token identification, a campaign identification that identifies the content campaign associated with the virtual token, and user-identified platform identifications that identify the platforms on which the user consents to be targeted by the content campaign; determining, based on the received electronic content data and user data, the content campaign and platforms the user consents to; and generating a notification to initiate a content campaign targeting the user on the platforms on which the user consents to be targeted; and outputting the generated notification to the platforms on which the user consents to be targeted.

Abstract: A method includes receiving inputs from a plurality of data providers reflecting the plurality of data providers' respective parameters for providing message channel data; receiving inputs from a plurality of data recipients reflecting the data recipients' respective parameters for receiving message channel data; identifying, using a matching engine, message channel data that matches the parameters of at least one of the plurality of data providers and the parameters of at least one of the data recipients; processing the message channel data in accordance with the parameters of the data providers, the processing step comprising segmenting the message channel data into permitted data segments and non-permitted data segments based on the data providers' parameters; delivering the permitted data segments to the identified data recipients in accordance with their respective parameters; and initiating a request for compensation of the identified data providers in accordance with their respective parameters.

Abstract: The present teaching relates to communication related to predictions. A communication chain is created with multiple chain units, each operating independently to provide prediction services related to a prompt with embedded information therein associated with predictions for the prompt to enable prediction services. A request is received for a requested operation related to a query prompt on one of prediction solicitation, prediction entry, verification entry, and prediction access. If a chain unit for the query prompt, the request is directed to the chain unit to perform the requested operation. If not, a new chain unit is created for the query prompt and the request is forwarded to the new chain unit to carry out the requested operation.

Abstract: Systems and methods to determine and ensure proper usage technique of a respiratory medicament device for a respiratory ailment. Medication data relating to a medication plan for a patient is collected and used to determine the respiratory medicament device type in use. For respiratory medicament device types requiring multiple consecutive uses, use data is collected and used to determine proper or improper use technique based on the timing between consecutive uses of the respiratory medicament device. Notification of proper or improper usage technique are provided based on the determined usage technique. Real-time monitoring of the use data is used to provide directions on the required timing of consecutive uses of the respiratory medicament device and thus ensure proper usage technique.

Abstract: A process for removal of heavy metal contaminants from organic compounds, especially campthothecin analogs.